ZFIN ID: ZDB-GENE-990415-162
Gene Name: MYC proto-oncogene, bHLH transcription factor a
Gene Symbol: myca    Nomenclature History

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Previous Names: c-myc (1), cmyc, cmyca, C-Myc1 (1), zc-myc (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in hematopoietic stem cell differentiation; regulation of vasculature development; and vasculature development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); prostate cancer (multiple); and urinary bladder cancer. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pronephros. Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor).
Genome Resources: Alliance (1),  Gene:30686 (1),  Ensembl(GRCz11):ENSDARG00000045695 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
nju52 Insertion Exon 2 Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • uf2 Small Deletion Exon 2 Frameshift, Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-myca 1
    MO1-myca N/A 2
    MO2-myca N/A 2
    MO3-myca N/A 1
    PHENOTYPE
    Data: Fig. 5 from Shi et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH myca HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Burkitt lymphoma Alliance Burkitt lymphoma, somatic 113970
    DISEASE ASSOCIATED WITH myca VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hematopoietic stem cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003327 Leucine zipper, Myc
    Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Domain IPR012682 Transcription regulator Myc, N-terminal
    Family IPR002418 Transcription regulator Myc
    Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myca-201 (1)    Ensembl 1864
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myca
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(crybb1:mCherry,LEXOP:EGFP-myca) crybb1LEXOP EGFPmCherrymyca Danio rerio 1 2
    Tg(hsp70l:VP16-myca,cryaa:ECFP) cryaahsp70l ECFPmycaVP16 Danio rerio 1 1
    MARKER RELATIONSHIPS
    myca Contained in: [BAC] CH211-69L10 (1)
    myca Encodes: [EST] fc77a09 (1)
    [cDNA] MGC:64149 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131412 (1) 1869 nt
    Genomic GenBank:CT573344 (1) 106999 nt
    Select Tool
    Polypeptide UniProtKB:F1RC36 (1) 409 aa
    Sequence Information (all 17)
    ORTHOLOGY for myca ( Chr: 24 )
    CITATIONS (149)