Gene

myca

ID
ZDB-GENE-990415-162
Name
MYC proto-oncogene, bHLH transcription factor a
Symbol
myca Nomenclature History
Previous Names
  • c-myc (1)
  • cmyc
  • cmyca
  • C-Myc1 (1)
  • zc-myc (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hematopoietic stem cell differentiation; regulation of vasculature development; and vasculature development. Predicted to be located in nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pronephros. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); prostate cancer (multiple); and urinary bladder cancer. Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
67 figures from 51 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Shi et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Burkitt lymphoma Alliance Burkitt lymphoma, somatic 113970
Associated With myca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003327 Leucine zipper, Myc
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Domain IPR012682 Transcription regulator Myc, N-terminal
Family IPR002418 Transcription regulator Myc
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Leucine zipper, Myc Myc-type, basic helix-loop-helix (bHLH) domain Transcription regulator Myc Transcription regulator Myc, N-terminal
UniProtKB:B8LFK4 403
UniProtKB:P52160 408
UniProtKB:F1RC36 409
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations