ZFIN ID: ZDB-GENE-990415-122
Gene Name: pancreatic and duodenal homeobox 1
Gene Symbol: pdx1
Previous Names: pdx-1 (1), ipf1 (1), pancreatic and duodenal homeobox gene 1, zgc:100874
Location: Chr: 24   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 68 figures from 48 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu283]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  anterior pancreatic bud, endocrine pancreas, endoderm, extrapancreatic duct (all 21) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 3 Genotypes
Knockdown reagents: MO1-pdx1 (1)

Allele Type Mutagen Suppliers
sa12 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: 4 figures from 3 publications
    Observed in: acinar cell, determination of digestive tract left/right asymmetry, determination of liver left/right asymmetry, determination of pancreatic left/right asymmetry (all 14) expand
    DISEASE ASSOCIATED WITH pdx1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    maturity-onset diabetes of the young MODY, type IV 606392
    pancreatic agenesis Pancreatic agenesis 1 260370
    type 2 diabetes mellitus {Diabetes mellitus, type II, susceptibility to} 125853
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endocrine pancreas development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR017995 (1)
  • InterPro:IPR020479 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pdx1-001 (1) 1117
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-pdx1 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pdx1
    Tg(-6.5pdx1:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pdx1 Contained in: [BAC] CH211-140B10 (1) (order this)
    pdx1 Encodes: [EST] eu283 (1)
    [cDNA] MGC:100874 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131443 (1) 1136 bp
    Genomic GenBank:BX571696 (1) 171175 bp
    Select Tool
    Polypeptide UniProtKB:F1RBA3 (1) 246 aa
    Sequence Clusters UniGene:75810 (1)
    Sequence Information (all 14)
    OTHER pdx1 GENE PAGES
  • Gene:30721 (1)
  • VEGA:OTTDARG00000021354 (1)
  • Ensembl(Zv9):ENSDARG00000002779 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL NS
    Zebrafish pdx1 24  
    Human PDX1 13 (13q12.1)
  • OMIM:600733
  • Gene:3651
  • Mouse Pdx1 5 ( 86.84 cM)
  • MGI:102851
  • Gene:18609
  • Orthology Details
    CITATIONS (97)