Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-990415-122
Gene Name: pancreatic and duodenal homeobox 1
Gene Symbol: pdx1
Previous Names: ipf1 (1), pdx-1 (1), pancreatic and duodenal homeobox gene 1, zgc:100874
Location: Chr: 24   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 63 figures from 43 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu283]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  anterior pancreatic bud, endocrine pancreas, endoderm, extrapancreatic duct (all 16) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 3 genotypes
Alleles: sa12
Knockdown reagents: MO1-pdx1 (1)
PHENOTYPE
Data: 4 figures from 3 publications
Observed in: acinar cell, determination of digestive tract left/right asymmetry, determination of liver left/right asymmetry, determination of pancreatic left/right asymmetry (all 14) expand

Phenotype of Human Orthologue OMIM Phenotype ID
MODY, type IV 606392
Pancreatic agenesis 260370
{Diabetes mellitus, type II, susceptibility to} 125853
GENE ONTOLOGY
Ontology GO Term
Biological Process endocrine pancreas development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR017995 (1)
  • InterPro:IPR020479 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pdx1-001 (1) 1117
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-pdx1 (1)
    CONSTRUCTS WITH SEQUENCES FROM pdx1
    Tg(-6.5pdx1:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pdx1 Contained in: [BAC] CH211-140B10 (1) (order this)
    pdx1 Encodes: [EST] eu283 (1)
    [cDNA] MGC:100874 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131443 (1) 1136 bp
    Genomic GenBank:BX571696 (1) 171175 bp
    Select Tool
    Polypeptide UniProtKB:F1RBA3 (1) 246 aa
    Sequence Clusters UniGene:75810 (1)
    Sequence Information (all 14)
    OTHER pdx1 GENE PAGES
  • Gene:30721 (1)
  • VEGA:OTTDARG00000021354 (1)
  • Ensembl(Zv9):ENSDARG00000002779 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL NS
    Zebrafish pdx1 24  
    Human PDX1 13 (13q12.1)
  • OMIM:600733
  • Gene:3651
  • Mouse Pdx1 5 ( 86.84 cM)
  • MGI:102851
  • Gene:18609
  • Orthology Details
    CITATIONS (92)