ZFIN ID: ZDB-GENE-990415-122
Gene Name: pancreatic and duodenal homeobox 1
Gene Symbol: pdx1    Nomenclature History

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Previous Names: pdx-1 (1), ipf1 (1), pancreatic and duodenal homeobox gene 1, zgc:100874

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in determination of left/right symmetry; endocrine pancreas development; and glucose homeostasis. Predicted to localize to nucleus. Is expressed in several structures, including digestive system; endoderm; intestinal rod; liver primordium; and somite. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1).
Genome Resources: Alliance (1),  Gene:30721 (1),  Ensembl(GRCz11):ENSDARG00000002779 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa280 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa3263 Point Mutation Unknown Premature Stop ENU
    sa37883 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pdx1
    1
    MO1-pdx1 N/A 13
    MO2-pdx1 N/A 1
    DISEASE ASSOCIATED WITH pdx1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    maturity-onset diabetes of the young type 4 Alliance MODY, type IV 606392
    pancreatic agenesis Alliance Pancreatic agenesis 1 260370
    type 2 diabetes mellitus Alliance {Diabetes mellitus, type II, susceptibility to} 125853
    DISEASE ASSOCIATED WITH pdx1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    diabetes mellitus pdx1sa280/sa280 standard conditions Kimmel et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endocrine pancreas development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pdx1-201 (1)    Ensembl 1117
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-pdx1 polyclonal Guinea pig IHC 6
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pdx1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-6.5pdx1:GFP) pdx1 GFP Danio rerio 1 8
    tgbac(pdx1:cre-ert2) pdx1 CreERT2 Danio rerio 1 1
    tgbac(pdx1:egfp) pdx1 EGFP Danio rerio 1 1
    tgbac(pdx1:luciferase) pdx1 Luciferase Danio rerio 1 1
    MARKER RELATIONSHIPS
    pdx1 Contained in: [BAC] CH211-140B10 (1)
    pdx1 Encodes: [EST] eu283 (1)
    [cDNA] MGC:100874 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131443 (1) 1140 nt
    Genomic GenBank:BX571696 (1) 171175 nt
    Select Tool
    Polypeptide UniProtKB:F1RBA3 (1) 246 aa
    Sequence Information (all 14)
    ORTHOLOGY for pdx1 ( Chr: 24 )
    CITATIONS (145)