ZFIN ID: ZDB-GENE-980526-501
Gene Name: T-cell acute lymphocytic leukemia 1
Gene Symbol: tal1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: tal-1, scl/tal1, scl, zgc:85605 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Exhibits sequence-specific DNA binding activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of endothelial cell differentiation. Predicted to localize to nucleus. Is expressed in several structures, including cardiovascular system; hematopoietic cell; hematopoietic system; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor).
Genome Resources: Alliance (1),  Gene:30766 (1),  Ensembl(GRCz11):ENSDARG00000019930 (2)
GENE EXPRESSION
All Expression Data: 316 figures from 206 publications
Directly Submitted Expression Data: 6 figures (25 images) from Thisse et al., 2004 [MGC:85605]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
t21384 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tal1 N/A 8
    MO2-tal1 N/A 6
    MO3-tal1 N/A 2
    MO4-tal1 N/A 16
    MO5-tal1 N/A 4
    MO6-tal1 N/A 4
    MO7-tal1 N/A 6
    MO8-tal1 N/A 3
    MO9-tal1 N/A 1
    DISEASE ASSOCIATED WITH tal1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute lymphoblastic leukemia Alliance Leukemia, T-cell acute lymphocytic, somatic 613065
    DISEASE ASSOCIATED WITH tal1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hemangioblast cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ottdart00000001376 (1) 2510
    tal1-201 (1)    Ensembl 2643
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tal1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-5.0tal1:EGFP) tal1 EGFP Danio rerio 2 5
    Tg(-6tal1:EGFP) tal1 EGFP Danio rerio 1 7
    Tg(tal1-Xla.Eef1a1:EGFP) tal1 EGFP Danio rerioXenopus laevis 1 1
    Tg(Tru.Lck:tal1) tal1 Danio rerioTakifugu rubripes 2 3
    Tg2(-5.0tal1:EGFP) tal1 EGFP Danio rerio 1 2
    TgPAC(tal1:d2EGFP) tal1 d2EGFP Danio rerio 1 5
    TgPAC(tal1:d2EGFP,tal1:DsRed) tal1 d2EGFPDsRed Danio rerio 1 3
    TgPAC(tal1:DsRed) tal1 DsRed Danio rerio 1 5
    TgPAC(tal1:EGFP) tal1 EGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    tal1 Contained in: [BAC] CH211-135J1 (1), DKEY-38N4 (1) (order this)
    [PAC] BUSM1-129I22 (1)
    tal1 Encodes: [cDNA] MGC:85605
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213237 (1) 2655 nt
    Genomic GenBank:BX322568 (1) 134716 nt
    Select Tool
    Polypeptide UniProtKB:O93507 (1) 324 aa
    Sequence Information (all 22)
    ORTHOLOGY for tal1 ( Chr: 22 )
    CITATIONS (367)