Gene

tal1

ID
ZDB-GENE-980526-501
Name
T-cell acute lymphocytic leukemia 1
Symbol
tal1 Nomenclature History
Previous Names
  • tal-1
  • scl/tal1
  • scl
  • zgc:85605 (1)
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Enables sequence-specific DNA binding activity. Involved in definitive hemopoiesis; endocardium formation; and myeloid cell differentiation. Acts upstream of or within several processes, including animal organ development; circulatory system development; and positive regulation of endothelial cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; hematopoietic cell; hematopoietic system; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
322 figures from 210 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
25 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tal1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute lymphoblastic leukemia Alliance Leukemia, T-cell acute lymphocytic, somatic 613065
Associated With tal1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:O93507 324
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations