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ZIRC
ZFIN ID: ZDB-GENE-980526-442
Gene Name: growth differentiation factor 6b
Gene Symbol: gdf6b    Nomenclature History

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Previous Names: bmp13b (1), dynamo (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have cytokine activity and transforming growth factor beta receptor binding activity. Predicted to be involved in several processes, including regulation of apoptotic process; regulation of protein phosphorylation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Klippel-Feil syndrome; Leber congenital amaurosis 17; cleft lip; isolated microphthalmia 4; and multiple synostoses syndrome. Orthologous to human GDF6 (growth differentiation factor 6).
Genome Resources: Alliance (1),  Gene:30180 (1),  Ensembl(GRCz11):ENSDARG00000005510 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Segmentation:20-25 somites (19.0h-22.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23521 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36836 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43280 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gdf6b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gdf6b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    isolated microphthalmia 4 Alliance Microphthalmia, isolated 4 613094
    Klippel-Feil syndrome 1 Alliance Klippel-Feil syndrome 1, autosomal dominant 118100
    Leber congenital amaurosis 17 Alliance Leber congenital amaurosis 17 615360
    Microphthalmia with coloboma 6, digenic 613703
    Multiple synostoses syndrome 4 617898
    DISEASE ASSOCIATED WITH gdf6b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process BMP signaling pathway (more)
    Cellular Component extracellular region (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 7)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gdf6b-201 (1)    Ensembl 1610
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gdf6b No data available
    MARKER RELATIONSHIPS
    gdf6b Contained in: [BAC] CH211-244A23 (1) (order this), DKEY-158E13 (1) (order this)
    gdf6b Encodes: [EST] fc13c07 (1)
    [cDNA] MGC:194755 (1) (order this), MGC:194772 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130987 (1) 1354 bp
    Genomic GenBank:BX571825 (1) 200814 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A8E7N9 (1) 412 aa
    Sequence Clusters UniGene:75756 (1)
    Sequence Information (all 20)
    ORTHOLOGY for gdf6b ( Chr: 19 )
    CITATIONS (33)