ZFIN ID: ZDB-GENE-980526-312
Gene Name: muscle segment homeobox 1a
Gene Symbol: msx1a    Nomenclature History

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Previous Names: msh-E, mshE, msx1 (1), msxe (1), cb435 (1), id:ibd5099, zgc:111928

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in otic placode formation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in cleft lip; cleft palate; orofacial cleft 5; tooth and nail syndrome; and tooth disease (multiple). Is expressed in several structures, including immature eye; nervous system; neural keel; pharyngeal arch; and regenerating fin. Orthologous to human MSX1 (msh homeobox 1).
Genome Resources: Alliance (1),  Gene:30527 (1),  Ensembl(GRCz11):ENSDARG00000116118 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-msx1a N/A 1
MO2-msx1a N/A 1
DISEASE ASSOCIATED WITH msx1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
orofacial cleft 5 Alliance Orofacial cleft 5 608874
tooth agenesis Alliance Tooth agenesis, selective, 1, with or without orofacial cleft 106600
tooth and nail syndrome Alliance Ectodermal dysplasia 3, Witkop type 189500
DISEASE ASSOCIATED WITH msx1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process otic placode formation (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR020479 Homeobox domain, metazoa
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM msx1a No data available
MARKER RELATIONSHIPS
msx1a Encodes: [EST] cb435 (1) (order this), ibd5099
[cDNA] MGC:111928 (1), MGC:193880 (1), MGC:193889 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001033589 (1)
Polypeptide UniProtKB:B3DG59 (1) 233 aa
Sequence Information (all 23)
ORTHOLOGY for msx1a ( Chr: 14 )
CITATIONS (59)