ZFIN ID: ZDB-PUB-080902-22
The Zebrafish Genome: A Review and msx Gene Case Study
Postlethwait, J.H.
Date: 2006
Source: Genome dynamics 2: 183-197 (Review)
Registered Authors: Postlethwait, John H.
Keywords: none
MeSH Terms: Animals; Computational Biology; Evolution, Molecular; Genetic Techniques; Genome (all 14) expand
PubMed: 18753779 Full text @ Genome Dyn.
ABSTRACT
Zebrafish is one of several important teleost models for understanding principles of vertebrate developmental, molecular, organismal, genetic, evolutionary, and genomic biology. Efficient investigation of the molecular genetic basis of induced mutations depends on knowledge of the zebrafish genome. Principles of zebrafish genomic analysis, including gene mapping, ortholog identification, conservation of syntenies, genome duplication, and evolution of duplicate gene function are discussed here using as a case study the zebrafish msxa, msxb, msxc, msxd, and msxe genes, which together constitute zebrafish orthologs of tetrapod Msx1, Msx2, and Msx3. Genomic analysis suggests orthologs for this difficult to understand group of paralogs.
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