ZFIN ID: ZDB-GENE-980526-26
Gene Name: muscle segment homeobox 1b
Gene Symbol: msx1b    Nomenclature History

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Previous Names: msh-B, mshB, msxB, msxb (1), etID309829.1 (1), wu:fk04h02, zgc:110559

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic organ morphogenesis; fin regeneration; and regulation of neuron apoptotic process. Predicted to localize to the nucleus. Is expressed in several structures, including central nervous system; fin; fin bud; germ ring; and median fin fold.
Genome Resources: Alliance (1),  Gene:30511 (1),  Ensembl(GRCz11):ENSDARG00000008886 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa39680 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-msx1b N/A 2
    MO2-msx1b N/A 1
    MO3-msx1b N/A 1
    MO4-msx1b N/A 1
    DISEASE ASSOCIATED WITH msx1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH msx1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal/ventral pattern formation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017970 Homeobox, conserved site
    Domain IPR001356 Homeobox domain
    Domain IPR020479 Homeobox domain, metazoa
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA msx1b-201 (1)    Ensembl 1424
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-msx monoclonal IgG1 , k Mouse IHC Developmental Studies Hybridoma Bank
    5
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM msx1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-6.5msx1b:EGFP) msx1b EGFP Danio rerio 1 5
    Tg(msx1b:EGFP) msx1b EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    msx1b Contained in: [BAC] DKEYP-80C12 (1)
    msx1b Encodes: [EST] fk04h02 (1)
    [cDNA] MGC:110559 (1), MGC:192593 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131260 (1) 1414 nt
    Genomic GenBank:CR812943 (1) 225846 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B2GSG0 (1) 257 aa
    Sequence Information (all 21)
    ORTHOLOGY for msx1b ( Chr: 1 )
    CITATIONS (127)