ZFIN ID: ZDB-GENE-980526-255
Gene Name: fibroblast growth factor receptor 1a
Gene Symbol: fgfr1a    Nomenclature History

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Previous Names: fgfr1, cb231 (1), sb:cb231

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Exhibits fibroblast growth factor-activated receptor activity. Involved in several processes, including animal organ development; fin regeneration; and negative regulation of endodermal cell fate specification. Predicted to localize to the integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; acrocephalosyndactylia (multiple); cleft lip; hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Is expressed in several structures, including head; integument; intestine; nervous system; and trunk vasculature. Orthologous to human FGFR1 (fibroblast growth factor receptor 1).
Genome Resources: Alliance (1),  Gene:30705 (1),  Ensembl(GRCz11):ENSDARG00000011027 (2)
GENE EXPRESSION
All Expression Data: 63 figures from 44 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2001 [cb231]
  6 figures (13 images) from Thisse et al., 2005 [eu444]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3264 Point Mutation Unknown Premature Stop ENU
la026639Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029507Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1689 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6106 Point Mutation Unknown Premature Stop ENU
    sa12393 Point Mutation Unknown Missense, Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16812 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21393 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21394 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21395 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34510 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38715 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t2227 Point Mutation Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-fgfr1a
    1
    MO1-fgfr1a N/A 15
    MO2-fgfr1a N/A 4
    MO3-fgfr1a N/A 3
    DISEASE ASSOCIATED WITH fgfr1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypogonadotropic hypogonadism 2 with or without anosmia Alliance Hypogonadotropic hypogonadism 2 with or without anosmia 147950
    Jackson-Weiss syndrome Alliance Jackson-Weiss syndrome 123150
    osteoglophonic dysplasia Alliance Osteoglophonic dysplasia 166250
    Pfeiffer syndrome Alliance Pfeiffer syndrome 101600
    Encephalocraniocutaneous lipomatosis, somatic mosaic 613001
    Hartsfield syndrome 615465
    Trigonocephaly 1 190440
    DISEASE ASSOCIATED WITH fgfr1a VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Domain IPR013098 Immunoglobulin I-set
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Family IPR016248 Fibroblast growth factor receptor family
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Domain IPR028174 Fibroblast growth factor receptor 1, catalytic domain
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    Domain IPR041159 Fibroblast growth factor receptor, transmembrane domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript fgfr1a-202 (1)    Ensembl 2381
    mRNA fgfr1a-201 (1)    Ensembl 2430
    fgfr1a-203 (1)    Ensembl 2190
    fgfr1a-204 (1)    Ensembl 7050
    ncRNA fgfr1a-006 (1)    Ensembl 871
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    AB1-fgfr1a monoclonal Mouse IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fgfr1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(-1.5hsp70l:loxp-stop-loxp-dnfgfr1a-cerulean-caax,cryaa:yfp) cryaahsp70l CAAXCeruleanfgfr1aLOXPYFP Danio rerio 1 1
    Tg(fabp10a:dnfgfr1-EGFP) fabp10a EGFPfgfr1a Danio rerio 1 3
    Tg(hsp70l:dnfgfr1a-EGFP) hsp70l EGFPfgfr1a Danio rerio 1 98
    Tg(lepb:dnfgfr1a-EGFP,eef1a1l1:NLS-mCherry) eef1a1l1lepb EGFPfgfr1amCherryNLS Danio rerio 2 1
    Tg(LLE-lepb:dnfgfr1a-EGFP,eef1a1l1:NLS-mCherry) eef1a1l1lepbLLE EGFPfgfr1amCherryNLS Danio rerio 1 1
    Tg(UAS:dnfgfr1a,myl7:EGFP) myl7 EGFPfgfr1a Danio rerio 1 3
    MARKER RELATIONSHIPS
    fgfr1a Contained in: [BAC] CH211-198O12 (1), DKEY-111H22 (1) (order this)
    fgfr1a Encodes: [EST] cb231 (1) (order this), eu444 (1)
    [cDNA] cssl:d107 (1), MGC:193969 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152962 (1) 2532 bp
    Genomic GenBank:CR376860 (1) 195545 bp
    Select Tool
    Polypeptide UniProtKB:Q90Z00 (1) 810 aa
    Sequence Information (all 39)
    ORTHOLOGY for fgfr1a ( Chr: 8 )
    CITATIONS (228)