ZFIN ID: ZDB-GENE-980526-255
Gene Name: fibroblast growth factor receptor 1a
Gene Symbol: fgfr1a
Sequence Ontology ID : SO:0000704

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Previous Names: fgfr1, cb231 (1), sb:cb231

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(Including Attributions)
Location: Chr: 8 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 53 figures from 37 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2001 [cb231]
  6 figures (13 images) from Thisse et al., 2005 [eu444]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
  anatomical structure, basal plate midbrain region, brain, caudal vein plexus (all 78) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3264 Point Mutation Unknown Premature Stop ENU
la026639Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029507Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1689 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6106 Point Mutation Unknown Premature Stop ENU
    sa12393 Point Mutation Unknown Splice Site, Nonsynonymous ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16812 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21393 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21394 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa21395 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34510 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa38715 Point Mutation Unknown Premature Stop ENU
    t2227 Point Mutation Unknown Unknown
    Targeting reagents: MO1-fgfr1a (1), MO2-fgfr1a (1), MO3-fgfr1a (1)
    PHENOTYPE
    Data: 4 figures from 3 publications
    Observed in: cranial nerve I axon, Kupffer's vesicle cilium, olfactory bulb glomerulus, olfactory epithelium (all 7) expand
    DISEASE ASSOCIATED WITH fgfr1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    hypogonadotropic hypogonadism 2 with or without anosmia Hypogonadotropic hypogonadism 2 with or without anosmia 147950
    Pfeiffer syndrome Pfeiffer syndrome 101600
    Osteoglophonic dysplasia 166250
    Encephalocraniocutaneous lipomatosis 613001
    Trigonocephaly 1 190440
    Jackson-Weiss syndrome 123150
    Encephalocraniocutaneous lipomatosis 613001
    Hartsfield syndrome 615465
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fibroblast growth factor receptor signaling pathway (more)
    Cellular Component integral component of plasma membrane (more)
    Molecular Function fibroblast growth factor-activated receptor activity (more)
    GO Terms (all 37)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719
  • InterPro:IPR001245
  • InterPro:IPR003598
  • InterPro:IPR003599
  • InterPro:IPR007110
  • InterPro:IPR008266
  • InterPro:IPR011009
  • InterPro:IPR013098
  • InterPro:IPR013783
  • InterPro:IPR016248
  • InterPro:IPR017441
  • InterPro:IPR020635
  • InterPro:IPR028174
  • PROSITE:PS00107
  • PROSITE:PS00109
  • PROSITE:PS50011
  • PROSITE:PS50835
  • Pfam:PF07679
  • Pfam:PF07714
  • EC:2.7.10.1
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA fgfr1a-001 (1) 7050
    fgfr1a-002 (1) 2190
    fgfr1a-003 (1) 2430
    aberrant processed transcript fgfr1a-004 (1) 2381
    ncRNA fgfr1a-005 (1) 2532
    fgfr1a-006 (1) 871
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    AB1-fgfr1a (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM fgfr1a
    Tg(fabp10a:dnfgfr1-EGFP), Tg(hsp70l:dnfgfr1a-EGFP), tg(lepb:dnfgfr1a-egfp,eef1a1l1:nls-mcherry), tg(lle-lepb:dnfgfr1a-egfp,eef1a1l1:nls-mcherry), Tg(UAS:dnfgfr1a,myl7:EGFP)
    MARKER RELATIONSHIPS
    fgfr1aContained in: [BAC] CH211-198O12 (1) (order this), DKEY-111H22 (1) (order this)
    fgfr1aEncodes: [EST] cb231 (1) (order this), eu444 (1)
    [cDNA] cssl:d107 (1), MGC:193969 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152962 (1) 3150bp
    Genomic GenBank:CR376860 (1) 195545bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IEQ9 811aa
    Sequence Clusters UniGene:78806 (1)
    Sequence Information (all 43)
    OTHER fgfr1a GENE PAGES
  • Gene:30705 (1)
  • VEGA:OTTDARG00000011735 (1)
  • Ensembl(GRCz10):ENSDARG00000011027 (1)
  • ORTHOLOGY for fgfr1a (Chr: 8)
    CITATIONS (132)