ZFIN ID: ZDB-GENE-980526-221
Gene Name: desmin a
Gene Symbol: desma
Sequence Ontology ID : SO:0000704

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Previous Names: des, desm, cb290 (1), wu:fb59a12, zgc:109859

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(Including Attributions)
Location: Chr: 9 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have structural molecule activity; involved in several processes, including heart contraction, locomotory behavior, and muscle contraction; localizes to the Z disc; used to study  ...
GENE EXPRESSION
All Expression Data: 41 figures from 19 publications
Directly Submitted Expression Data: 12 figures (24 images) from Rauch et al., 2003 [fb59a12]
  6 figures (15 images) from Thisse et al., 2001 [cb290]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct122aGt Transgenic Insertion Unknown Unknown DNA
ct122aRGt Transgenic Insertion Unknown Unknown
sa5 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15298 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34555 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 12 figures from 3 publications
    Observed in:
    DISEASE ASSOCIATED WITH desma HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    dilated cardiomyopathy 1I Cardiomyopathy, dilated, 1I 604765
    myofibrillar myopathy 1 Myopathy, myofibrillar, 1 601419
    Scapuloperoneal syndrome, neurogenic, Kaeser type 181400
    DISEASE ASSOCIATED WITH desma VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    myofibrillar myopathy 1 desmact122aGt/ct122aGt control Ramspacher et al., 2015
    desmasa5/sa5 control Ramspacher et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process muscle contraction (more)
    Cellular Component Z disc (more)
    Molecular Function structural molecule activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001664 (1)
  • InterPro:IPR006821 (1)
  • InterPro:IPR018039 (1)
  • InterPro:IPR039008 (1)
  • PROSITE:PS00226 (1)
  • PROSITE:PS51842 (1)
  • Pfam:PF00038 (1)
  • Pfam:PF04732 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA desma-003 (1) 859
    mRNA desma-201 (1) 1774
    desma-202 (1) 1848
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM desma No data available
    MARKER RELATIONSHIPS
    desmaContained in: [BAC] CH73-129N15 (1) (order this)
    desmaEncodes: [EST] cb290 (1) (order this), fb59a12 (order this)
    [cDNA] MGC:109859 (1) (order this), MGC:192695 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130963 (1) 1798bp
    Genomic GenBank:CU861474 (1) 89132bp
    Select Tool
    Polypeptide UniProtKB:F1R8W3 (1) 488aa
    Sequence Clusters UniGene:75084 (1)
    Sequence Information (all 25)
    OTHER desma GENE PAGES
  • Alliance (1)
  • Gene:30148 (1)
  • VEGA:OTTDARG00000032776 (1)
  • Ensembl(GRCz11):ENSDARG00000058656 (2)
  • ORTHOLOGY for desma (Chr: 9)
    CITATIONS (71)