Gene

ntrk1

ID
ZDB-GENE-980526-118
Name
neurotrophic tyrosine kinase, receptor, type 1
Symbol
ntrk1 Nomenclature History
Previous Names
  • trk
  • trkA (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Involved in defense response to bacterium; inflammatory response to wounding; and neutrophil mediated immunity. Predicted to localize to axon; integral component of plasma membrane; and receptor complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1).
Genome Resources
Note
None
Expression
All Expression Data
9 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ntrk1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary sensory neuropathy type 4 Alliance Insensitivity to pain, congenital, with anhidrosis 256800
Associated With ntrk1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
Domain IPR040665 Tyrosine kinase receptor A, transmembrane domain
Family IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1
Family IPR020777 Tyrosine-protein kinase, neurotrophic receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Repeat IPR001611 Leucine-rich repeat
Domain Details Per Protein
Protein Length Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Leucine-rich repeat Leucine-rich repeat domain superfamily Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine kinase receptor A, transmembrane domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, neurotrophic receptor Tyrosine-protein kinase, neurotrophic receptor, type 1 Tyrosine-protein kinase, receptor class II, conserved site Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
UniProtKB:F6P1M3 797
UniProtKB:F1QB19 788
UniProtKB:Q91407 168
UniProtKB:G9JKB2 556
UniProtKB:B3DGZ3 619
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations