ZFIN ID: ZDB-GENE-980526-118
Gene Name: neurotrophic tyrosine kinase, receptor, type 1
Gene Symbol: ntrk1    Nomenclature History

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Previous Names: trk, trkA (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Involved in defense response to bacterium; inflammatory response to wounding; and neutrophil mediated immunity. Predicted to localize to axon; integral component of plasma membrane; and receptor complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1).
Genome Resources: Alliance (1),  Gene:30546 (1),  Ensembl(GRCz11):ENSDARG00000004586 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14939 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14955 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32109 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36252 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ntrk1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ntrk1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary sensory neuropathy type 4 Alliance Insensitivity to pain, congenital, with anhidrosis 256800
    DISEASE ASSOCIATED WITH ntrk1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process defense response to bacterium (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 31)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ntrk1-202 (1)    Ensembl 2663
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ntrk1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(mpeg1.1:ntrk1) mpeg1.1 ntrk1 Danio rerio 1 2
    MARKER RELATIONSHIPS
    ntrk1 Contained in: [BAC] DKEY-45N22 (1) (order this)
    ntrk1 Encodes: [cDNA] MGC:193825 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001301356 (1)
    Genomic GenBank:CR933818 (1) 243546 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F6P1M3 (1) 797 aa
    Sequence Information (all 16)
    ORTHOLOGY for ntrk1 ( Chr: 16 )
    CITATIONS (30)