ZFIN ID: ZDB-GENE-120927-1
Gene Name: minichromosome maintenance 8 homologous recombination repair factor
Gene Symbol: mcm8    Nomenclature History

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Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have DNA replication origin binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to localize to MCM complex and nucleus. Human ortholog(s) of this gene implicated in premature ovarian failure. Orthologous to human MCM8 (minichromosome maintenance 8 homologous recombination repair factor).
Genome Resources: Alliance (1),  Gene:100333576 (1),  Ensembl(GRCz11):ENSDARG00000074326 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10066 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36290 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mcm8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Premature ovarian failure 10 612885
    DISEASE ASSOCIATED WITH mcm8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process DNA replication (more)
    Cellular Component MCM complex (more)
    Molecular Function ATP binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mcm8-201 (1)    Ensembl 2915
    mcm8-202 (1)    Ensembl 700
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mcm8 No data available
    MARKER RELATIONSHIPS
    mcm8 Contained in: [Fosmid] CH1073-256P11 (1), CH1073-376H13 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002665115 (1)
    Genomic GenBank:CU929122 (1) 36688 nt
    Select Tool
    Polypeptide UniProtKB:E7F643 (1) 852 aa
    Sequence Information (all 12)
    ORTHOLOGY for mcm8 ( Chr: 17 )
    CITATIONS (15)