Gene

mcm8

ID
ZDB-GENE-120927-1
Name
minichromosome maintenance 8 homologous recombination repair factor
Symbol
mcm8 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have DNA replication origin binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to localize to MCM complex and nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency. Orthologous to human MCM8 (minichromosome maintenance 8 homologous recombination repair factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mcm8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary ovarian insufficiency 10 Alliance ?Premature ovarian failure 10 612885
Associated With mcm8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018525 Mini-chromosome maintenance, conserved site
Domain IPR001208 MCM domain
Domain IPR003593 AAA+ ATPase domain
Domain IPR033762 MCM OB domain
Domain IPR041562 MCM, AAA-lid domain
Family IPR031327 Mini-chromosome maintenance protein
Homologous_superfamily IPR012340 Nucleic acid-binding, OB-fold
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length AAA+ ATPase domain MCM, AAA-lid domain MCM domain MCM OB domain Mini-chromosome maintenance, conserved site Mini-chromosome maintenance protein Nucleic acid-binding, OB-fold P-loop containing nucleoside triphosphate hydrolase
UniProtKB:E7F643 852
UniProtKB:X1WEG1 151
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations