Community Action Needed: Please respond to the NIH RFI
Gene

iqsec1b

ID
ZDB-GENE-120813-1
Name
IQ motif and Sec7 domain ArfGEF 1b
Symbol
iqsec1b Nomenclature History
Previous Names
  • si:dkey-57n24.7
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Acts upstream of or within angiogenesis and lymphangiogenesis. Predicted to be located in cytoplasm. Is expressed in liver. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Ningappa et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Manavski et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With iqsec1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
intellectual developmental disorder with short stature and behavioral abnormalities Alliance Intellectual developmental disorder with short stature and behavioral abnormalities 618687
Associated With iqsec1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR000904 Sec7 domain
Domain IPR033742 IQ motif and SEC7 domain-containing protein, PH domain
Family IPR030737 IQ motif and SEC7 domain-containing protein 1
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR023394 Sec7, C-terminal domain superfamily
Homologous_superfamily IPR035999 Sec7 domain superfamily
Domain Details Per Protein
Protein Length IQ motif and SEC7 domain-containing protein 1 IQ motif and SEC7 domain-containing protein, PH domain IQ motif, EF-hand binding site PH-like domain superfamily Sec7, C-terminal domain superfamily Sec7 domain Sec7 domain superfamily
UniProtKB:E7EZE5 1252
UniProtKB:X1WBR0 1134
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations