ZFIN ID: ZDB-GENE-120813-1
Gene Name: IQ motif and Sec7 domain ArfGEF 1b
Gene Symbol: iqsec1b    Nomenclature History

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Previous Name: si:dkey-57n24.7

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have ARF guanyl-nucleotide exchange factor activity. Involved in angiogenesis and lymphangiogenesis. Is expressed in liver. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1).
Genome Resources: Alliance (1),  Gene:100148736 (1),  Ensembl(GRCz11):ENSDARG00000016551 (2)
GENE EXPRESSION
All Expression Data: Fig. 6 from Ningappa et al., 2015
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Larval:Day 4 (96.0h-120.0h)
 
DISEASE ASSOCIATED WITH iqsec1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
intellectual developmental disorder with short stature and behavioral abnormalities Alliance Intellectual developmental disorder with short stature and behavioral abnormalities 618687
DISEASE ASSOCIATED WITH iqsec1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process angiogenesis (more)
Molecular Function ARF guanyl-nucleotide exchange factor activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA iqsec1b-201 (1)    Ensembl 7336
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM iqsec1b No data available
MARKER RELATIONSHIPS
iqsec1b Contained in: [BAC] CH211-44M8 (1), CH211-127I19 (1), CH211-202F21 (1), DKEY-57N24 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_005169331 (1) 7654 nt
Genomic GenBank:CR847934 (1) 199615 nt
Select Tool
Polypeptide UniProtKB:E7EZE5 (1) 1252 aa
Sequence Information (all 30)
ORTHOLOGY for iqsec1b ( Chr: 11 )
CITATIONS (17)