Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-110411-139
Gene Name: sclerostin
Gene Symbol: sost
Previous Name: si:dkeyp-44b3.1
Location: Chr: 12   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  basibranchial, central nervous system, ceratobranchial cartilage, ceratohyal cartilage (all 16) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS No data available
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Craniodiaphyseal dysplasia, autosomal dominant 122860
Sclerosteosis 1 269500
Van Buchem disease 239100
GENE ONTOLOGY
Ontology GO Term
Cellular Component extracellular space (more)
GO Terms (all 1)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR006207 (1)
  • InterPro:IPR008835 (1)
  • InterPro:IPR015665 (1)
  • InterPro:IPR029034 (1)
  • PROSITE:PS01225 (1)
  • Pfam:PF05463 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA sost-001 (1) 2238
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-sost (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sost No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    sost Contained in: [BAC] DKEYP-44B3 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001340647 (1) 2238 bp
    Genomic GenBank:CR932037 (1) 151672 bp
    Select Tool
    Polypeptide UniProtKB:E7EXX7 (1) 210 aa
    Sequence Information (all 4)
    OTHER sost GENE PAGES
  • Gene:100000500 (1)
  • VEGA:OTTDARG00000035684 (1)
  • Ensembl(Zv9):ENSDARG00000061259 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish sost 12  
    Human SOST 17 (17q11.2)
  • OMIM:605740
  • Gene:50964
  • Mouse Sost 11 ( 65.48 cM)
  • MGI:1921749
  • Gene:74499
  • Orthology Details
    CITATIONS (12)