Gene

sost

ID
ZDB-GENE-110411-139
Name
sclerostin
Symbol
sost Nomenclature History
Previous Names
  • si:dkeyp-44b3.1
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have BMP binding activity. Predicted to be involved in negative regulation of BMP signaling pathway; negative regulation of Wnt signaling pathway; and ossification. Predicted to localize to extracellular space. Is expressed in Kupffer's vesicle; basibranchial; nervous system; pectoral fin; and pharyngeal arch cartilage. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sost Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant craniodiaphyseal dysplasia Alliance Craniodiaphyseal dysplasia, autosomal dominant 122860
sclerosteosis 1 Alliance Sclerosteosis 1 269500
Associated With sost Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006207 Cystine knot, C-terminal
Family IPR008835 Sclerostin/Sclerostin domain-containing protein 1
Family IPR015665 Sclerostin
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine knot, C-terminal Cystine-knot cytokine Sclerostin Sclerostin/Sclerostin domain-containing protein 1
UniProtKB:E7EXX7 210
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-sost polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations