Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-110411-139
Gene Name: sclerostin
Gene Symbol: sost
Previous Name: si:dkeyp-44b3.1
Nomenclature History
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  basibranchial, central nervous system, ceratobranchial cartilage, ceratohyal cartilage (all 16) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS No data available
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Craniodiaphyseal dysplasia, autosomal dominant 122860
Sclerosteosis 269500
Van Buchem disease 239100
GENE ONTOLOGY
Ontology GO Term
Cellular Component extracellular space (more)
GO Terms (all 1)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR006207 (1)
  • InterPro:IPR008835 (1)
  • PROSITE:PS01225 (1)
  • Pfam:PF05463 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA sost-001 (1) 2238
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-sost (1)
    CONSTRUCTS WITH SEQUENCES FROM sost No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    sost Contained in: [BAC] DKEYP-44B3 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001340647 (1) 2238 bp
    Genomic GenBank:CR932037 (1) 151672 bp
    Select Tool
    Polypeptide UniProtKB:E7EXX7 (1) 210 aa
    Sequence Information (all 4)
    OTHER sost GENE PAGES
  • Gene:100000500 (1)
  • VEGA:OTTDARG00000035684 (1)
  • Ensembl(Zv9):ENSDARG00000061259 (1)
  • MAPPING INFORMATION
    Chr: 12 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish sost 12  
    Human SOST 17 (17q11.2)
  • OMIM:605740
  • Gene:50964
  • Mouse Sost 11 ( 65.48 cM)
  • MGI:1921749
  • Gene:74499
  • CITATIONS (12)