ZFIN ID: ZDB-GENE-110411-139
Gene Name: sclerostin
Gene Symbol: sost
Previous Name: si:dkeyp-44b3.1
Location: Chr: 12 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  basibranchial, central nervous system, ceratobranchial cartilage, ceratohyal cartilage (all 16) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTSNo data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH sost HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
craniometaphyseal dysplasia Craniodiaphyseal dysplasia, autosomal dominant 122860
sclerosteosis Sclerosteosis 1 269500
Van Buchem disease 239100
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of ossification (more)
Cellular Component extracellular region (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR006207 (1)
  • InterPro:IPR008835 (1)
  • InterPro:IPR015665 (1)
  • InterPro:IPR029034 (1)
  • PROSITE:PS01225 (1)
  • Pfam:PF05463 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA sost-001 (1) 2238
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-sost (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM sost No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    sostContained in: [BAC] DKEYP-44B3 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001340647 (1) 2238bp
    Genomic GenBank:CR932037 (1) 151672bp
    Select Tool
    Polypeptide UniProtKB:E7EXX7 (1) 210aa
    Sequence Information (all 4)
    OTHER sost GENE PAGES
  • Gene:100000500 (1)
  • VEGA:OTTDARG00000035684 (1)
  • Ensembl(GRCz10):ENSDARG00000061259 (1)
  • ORTHOLOGY for sost (Chr: 12)
    Species Symbol Chromosome Accession # Evidence
    Human SOST 17
  • Gene:50964
  • OMIM:605740
  • HGNC:13771
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse Sost 11
  • MGI:1921749
  • Gene:74499
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (13)