ZFIN ID: ZDB-GENE-110411-139
Gene Name: sclerostin
Gene Symbol: sost
Previous Name: si:dkeyp-44b3.1
Location: Chr: 12   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  basibranchial, central nervous system, ceratobranchial cartilage, ceratohyal cartilage (all 16) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH sost HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
craniometaphyseal dysplasia Craniodiaphyseal dysplasia, autosomal dominant 122860
sclerosteosis Sclerosteosis 1 269500
Van Buchem disease 239100
GENE ONTOLOGY
Ontology GO Term
Cellular Component extracellular region (more)
GO Terms (all 2)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR006207 (1)
  • InterPro:IPR008835 (1)
  • InterPro:IPR015665 (1)
  • InterPro:IPR029034 (1)
  • PROSITE:PS01225 (1)
  • Pfam:PF05463 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA sost-001 (1) 2238
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-sost (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sost No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    sost Contained in: [BAC] DKEYP-44B3 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001340647 (1) 2238 bp
    Genomic GenBank:CR932037 (1) 151672 bp
    Select Tool
    Polypeptide UniProtKB:E7EXX7 (1) 210 aa
    Sequence Information (all 4)
    OTHER sost GENE PAGES
  • Gene:100000500 (1)
  • VEGA:OTTDARG00000035684 (1)
  • Ensembl(Zv9):ENSDARG00000061259 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish sost 12  
    Human SOST 17 (17q11.2)
  • OMIM:605740
  • Gene:50964
  • Mouse Sost 11 ( 65.48 cM)
  • MGI:1921749
  • Gene:74499
  • Orthology Details
    CITATIONS (13)