ZFIN ID: ZDB-GENE-100917-2
Gene Name: plectin b
Gene Symbol: plecb    Nomenclature History

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Previous Name: si:ch211-24c14.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have ankyrin binding activity and structural molecule activity. Involved in locomotory behavior; myofibril assembly; and skeletal muscle tissue development. Predicted to colocalize with intermediate filament. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2Q; epidermolysis bullosa simplex; epidermolysis bullosa simplex Ogna type; and epidermolysis bullosa simplex with muscular dystrophy. Orthologous to human PLEC (plectin).
Genome Resources: Alliance (1),  Gene:100321011 (1),  Ensembl(GRCz11):ENSDARG00000021987 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct110bGt Transgenic Insertion Unknown Unknown DNA
la027789Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12243 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14270 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14343 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15190 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16747 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa28576 Point Mutation Unknown Premature Stop ENU
    sa36029 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36030 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42650 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42651 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • stl236 Small Deletion Exon 3 Frameshift, Premature Stop CRISPR
    tpl17Gt Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-plecb 1
    MO1-plecb N/A 1
    DISEASE ASSOCIATED WITH plecb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive limb-girdle muscular dystrophy type 2Q Alliance Muscular dystrophy, limb-girdle, autosomal recessive 17 613723
    epidermolysis bullosa simplex Ogna type Alliance Epidermolysis bullosa simplex, Ogna type 131950
    epidermolysis bullosa simplex with muscular dystrophy Alliance Epidermolysis bullosa simplex with muscular dystrophy 226670
    Epidermolysis bullosa simplex with pyloric atresia 612138
    ?Epidermolysis bullosa simplex with nail dystrophy 616487
    DISEASE ASSOCIATED WITH plecb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process locomotory behavior (more)
    Cellular Component cytoskeleton (more)
    Molecular Function actin binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA plecb-205 (1)    Ensembl 15557
    ncRNA plecb-002 (1)    Ensembl 698
    plecb-003 (1)    Ensembl 536
    plecb-004 (1)    Ensembl 546
    plecb-005 (1)    Ensembl 429
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM plecb No data available
    MARKER RELATIONSHIPS
    plecb Contained in: [BAC] CH211-24C14 (1), CH211-151O1 (1), DKEY-283B15 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009292039 (1)
    Genomic GenBank:CR848788 (1) 189441 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QR17 (1) 4535 aa
    Sequence Information (all 78)
    ORTHOLOGY for plecb ( Chr: 16 )
    CITATIONS (30)