ZFIN ID: ZDB-GENE-090728-1
Gene Name: collagen, type XII, alpha 1a
Gene Symbol: col12a1a    Nomenclature History

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Previous Names: col12a1, fa99f12, wu:fa99f12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Involved in regeneration and regulation of axon regeneration. Predicted to localize to collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including immature eye; integument; myoseptum; nervous system; and trunk vasculature. Human ortholog(s) of this gene implicated in Ullrich congenital muscular dystrophy. Orthologous to human COL12A1 (collagen type XII alpha 1 chain).
Genome Resources: Alliance (1),  Gene:100149543 (1),  Ensembl(GRCz11):ENSDARG00000078322 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa850 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12155 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-col12a1a
    1
    MO1-col12a1a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH col12a1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Bethlem myopathy 2 616471
    ?Ullrich congenital muscular dystrophy 2 616470
    DISEASE ASSOCIATED WITH col12a1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regeneration (more)
    Cellular Component collagen trimer (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA col12a1a-201 (1)    Ensembl 10560
    col12a1a-202 (1)    Ensembl 940
    ncRNA col12a1a-002 (1) 630
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-col12a1 polyclonal Rabbit IHC 5
    Ab2-col12a1 polyclonal Guinea pig IHC, WB 3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM col12a1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:col12a1a-p2A-Cerulean) hsp70l 2ACeruleancol12a1a Danio rerio 1 2
    MARKER RELATIONSHIPS
    col12a1a Contained in: [BAC] CH73-133O19 (1), CH73-213I16 (1)
    [Fosmid] CH1073-18E6 (1), CH1073-327K3 (1), ZFOS-756G12 (1)
    col12a1a Encodes: [EST] fa99f12
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002665259 (1) 10557 nt
    Genomic GenBank:CU693377 (1) 93968 nt
    Select Tool
    Polypeptide UniProtKB:X1WF98 (1) 2975 aa
    Sequence Information (all 26)
    ORTHOLOGY for col12a1a ( Chr: 17 )
    CITATIONS (34)