Gene

pde6b

ID
ZDB-GENE-090421-2
Name
phosphodiesterase 6B, cGMP-specific, rod, beta
Symbol
pde6b Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have 3',5'-cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in retina development in camera-type eye and signal transduction. Predicted to localize to photoreceptor outer segment membrane. Is expressed in eye; retinal neural layer; and retinal photoreceptor layer. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 2 and retinitis pigmentosa 40. Orthologous to human PDE6B (phosphodiesterase 6B).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pde6b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital stationary night blindness autosomal dominant 2 Alliance Night blindness, congenital stationary, autosomal dominant 2 163500
retinitis pigmentosa 40 Alliance Retinitis pigmentosa-40 613801
Associated With pde6b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain IPR003018 GAF domain
Domain IPR003607 HD/PDEase domain
Family IPR023088 3'5'-cyclic nucleotide phosphodiesterase
Homologous_superfamily IPR029016 GAF-like domain superfamily
Homologous_superfamily IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
Domain Details Per Protein
Protein Length 3'5'-cyclic nucleotide phosphodiesterase 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily 3'5'-cyclic nucleotide phosphodiesterase, conserved site GAF domain GAF-like domain superfamily HD/PDEase domain
UniProtKB:E7F5I9 854
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pde6b polyclonal IgG Rabbit
  • WB
Proteintech
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations