ZFIN ID: ZDB-GENE-090313-384
Gene Name: peptidylglycine alpha-amidating monooxygenase
Gene Symbol: pam    Nomenclature History

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Previous Name: si:dkeyp-35f12.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits peptidylglycine monooxygenase activity. Involved in ciliary basal body-plasma membrane docking and microvillus assembly. Predicted to localize to extracellular region. Is expressed in floor plate; gut; otic vesicle; and ventricular system. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase).
Genome Resources: Alliance (1),  Gene:570822 (1),  Ensembl(GRCz11):ENSDARG00000100170 (1)
GENE EXPRESSION
All Expression Data: Fig. 1 from Kumar et al., 2018
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mbg5 Indel Exon 1 Frameshift, Premature Stop CRISPR
mbg9 Small Deletion Exon 1 Frameshift, Premature Stop CRISPR
mbg10 Small Deletion Exon 1 Frameshift, Premature Stop CRISPR
sa15072 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16146 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21661 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34842 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45393 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pam 1
    DISEASE ASSOCIATED WITH pam HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pam VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ciliary basal body-plasma membrane docking (more)
    Cellular Component integral component of membrane (more)
    Molecular Function peptidylglycine monooxygenase activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pam-203 (1)    Ensembl 4083
    ncRNA pam-002 (1) 650
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pam No data available
    MARKER RELATIONSHIPS
    pam Contained in: [BAC] DKEYP-35F12 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005155504 (1)
    Genomic GenBank:BX294128 (1) 160042 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IIV2 (1) 1017 aa
    Sequence Information (all 25)
    ORTHOLOGY for pam ( Chr: 10 )
    CITATIONS (18)