Gene

pam

ID
ZDB-GENE-090313-384
Name
peptidylglycine alpha-amidating monooxygenase
Symbol
pam Nomenclature History
Previous Names
  • si:dkeyp-35f12.2 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Exhibits peptidylglycine monooxygenase activity. Involved in ciliary basal body-plasma membrane docking and microvillus assembly. Predicted to localize to extracellular region. Is expressed in floor plate; gut; otic vesicle; and ventricular system. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase).
Genome Resources
Note
None
Expression
All Expression Data
Fig. 1 from Kumar et al., 2018
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from Kumar et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pam Human Ortholog
No data available
Associated With pam Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
Domain IPR024548 Copper type II ascorbate-dependent monooxygenase, C-terminal
Family IPR000720 Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase
Homologous_superfamily IPR008977 PHM/PNGase F domain superfamily
Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
Homologous_superfamily IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
Homologous_superfamily IPR036939 Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Repeat IPR001258 NHL repeat
Repeat IPR013017 NHL repeat, subgroup
Domain Details Per Protein
Protein Length Copper type II ascorbate-dependent monooxygenase, C-terminal Copper type II, ascorbate-dependent monooxygenase-like, C-terminal Copper type II, ascorbate-dependent monooxygenase, N-terminal Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily NHL repeat NHL repeat, subgroup Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase PHM/PNGase F domain superfamily Six-bladed beta-propeller, TolB-like
UniProtKB:A0A2R8RHP7 598
UniProtKB:A0A2R8QJB3 500
UniProtKB:A0A0R4IFY7 699
UniProtKB:A0A0R4IIV2 1017
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations