ZFIN Gene: arhgef19

ZFIN ID: ZDB-GENE-090313-243

ZFIN ID: ZDB-GENE-090313-243

Gene Name:

Rho guanine nucleotide exchange factor (GEF) 19

Gene Symbol:

arhgef19

Sequence Ontology ID :

SO:0000704

Previous Name:

si:dkey-21o19.4

Location:

Chr: 23 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have Rho guanyl-nucleotide exchange factor activity. Involved in epidermis development and neural tube closure. Orthologous to human ARHGEF19 (Rho guanine nucleotide exchange factor 19).

GENE EXPRESSION
All Expression Data:	Fig. S2 from Miles et al., 2017
Wild-type Stages, Structures:	Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
	post-vent region integument

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa9613	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa9879	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa24325	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa29923	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa45800	Point Mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

MO1-arhgef19 (1)

PHENOTYPE

Data:	Fig. 3 from Miles et al., 2017
Observed in:	periderm cell

DISEASE ASSOCIATED WITH arhgef19 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH arhgef19 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	epidermis development (more)
Molecular Function	Rho guanyl-nucleotide exchange factor activity (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000219 (1) InterPro:IPR001452 (1) InterPro:IPR011993 (1) InterPro:IPR035899 (1) InterPro:IPR036028 (1)	PROSITE:PS50002 (1) PROSITE:PS50010 (1)	Pfam:PF00621 (1) Pfam:PF14604 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	arhgef19-202 (1)	1535	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION No description available

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM arhgef19 No data available

MARKER RELATIONSHIPS

arhgef19Contained in:

[BAC] DKEY-21O19 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
Genomic	GenBank:CR925709 (1)	151006bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7EY47 (1)	958aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 3)

OTHER arhgef19 GENE PAGES

Alliance (1)

VEGA:OTTDARG00000030435 (1)

Ensembl(GRCz11):ENSDARG00000078853 (2)

ORTHOLOGY for arhgef19 (Chr: 23)

CITATIONS (11)

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