Gene

cdkn2a/b

ID
ZDB-GENE-081104-306
Name
cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)
Symbol
cdkn2a/b Nomenclature History
Previous Names
  • cdkn2b
  • ink4b (1)
  • si:dkey-123o10.1
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Is expressed in eye; intestinal bulb; mid intestine; posterior intestine; and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and nervous system cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A) and CDKN2B (cyclin dependent kinase inhibitor 2B).
Genome Resources
Note
None
Expression
All Expression Data
8 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdkn2a/b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
melanoma and neural system tumor syndrome Alliance {Melanoma and neural system tumor syndrome} 155755
{Melanoma, cutaneous malignant, 2} 155601
{Melanoma-pancreatic cancer syndrome} 606719
Associated With cdkn2a/b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020683 Ankyrin repeat-containing domain
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily
UniProtKB:E9QFU2 125
UniProtKB:A0A2R8PZV6 129
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cdkn2b monoclonal IgG2a Rat
  • IHC
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations