ZFIN ID: ZDB-GENE-081104-306
Gene Name: cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)
Gene Symbol: cdkn2a/b
Sequence Ontology ID : SO:0000704

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Previous Names: cdkn2b, ink4b (1), si:dkey-123o10.1

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Location: Chr: 1 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Orthologous to several human genes including CDKN2B (cyclin dependent kinase inhibitor 2B).
GENE EXPRESSION
All Expression Data: 6 figures from 5 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa25583 Point Mutation Unknown Splice Site ENU
sa32685 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zk1 Small Deletion Exon 1 Frameshift TALEN
    zk2 Small Deletion Exon 1 Frameshift TALEN
    Targeting reagents:
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cdkn2a/b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Orolaryngeal cancer, multiple,
    Pancreatic cancer/melanoma syndrome 606719
    Melanoma and neural system tumor syndrome 155755
    {Melanoma, cutaneous malignant, 2} 155601
    Orolaryngeal cancer, multiple,
    Pancreatic cancer/melanoma syndrome 606719
    Melanoma and neural system tumor syndrome 155755
    {Melanoma, cutaneous malignant, 2} 155601
    DISEASE ASSOCIATED WITH cdkn2a/b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY No data available
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002110 (1)
  • InterPro:IPR020683 (1)
  • InterPro:IPR036770 (1)
  • PROSITE:PS50088 (1)
  • PROSITE:PS50297 (1)
  • Pfam:PF12796 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cdkn2a/b-001 (1) 378
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM cdkn2a/b No data available
    MARKER RELATIONSHIPS
    cdkn2a/bContained in: [BAC] CH211-145B13 (1) (order this), DKEY-123O10 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_002660468 (1)
    Genomic GenBank:CT573245 (1) 196368bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8PZV6 (1) 129aa
    Sequence Information (all 7)
    OTHER cdkn2a/b GENE PAGES
  • Alliance (1)
  • Gene:100329528 (1)
  • VEGA:OTTDARG00000027187 (1)
  • Ensembl(GRCz11):ENSDARG00000037262 (1)
  • ORTHOLOGY for cdkn2a/b (Chr: 1)
    CITATIONS (22)