ZFIN ID: ZDB-GENE-081104-306
Gene Name: cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)
Gene Symbol: cdkn2a/b    Nomenclature History

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Previous Names: cdkn2b, ink4b (1), si:dkey-123o10.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Is expressed in eye; intestinal bulb; mid intestine; posterior intestine; and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and nervous system cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A) and CDKN2B (cyclin dependent kinase inhibitor 2B).
Genome Resources: Alliance (1),  Gene:100329528 (1),  Ensembl(GRCz11):ENSDARG00000037262 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa25583 Point Mutation Unknown Splice Site ENU
sa32685 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zk1 Small Deletion Exon 1 Frameshift TALEN
    zk2 Small Deletion Exon 1 Frameshift TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cdkn2a/b
    1
    MO1-cdkn2a/b N/A 2
    TALEN1-cdkn2a/b 1
    TALEN2-cdkn2a/b
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cdkn2a/b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    melanoma and neural system tumor syndrome Alliance {Melanoma and neural system tumor syndrome} 155755
    {Melanoma, cutaneous malignant, 2} 155601
    {Melanoma-pancreatic cancer syndrome} 606719
    DISEASE ASSOCIATED WITH cdkn2a/b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdkn2a/b-201 (1)    Ensembl 378
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cdkn2b monoclonal IgG2a Rat IHC 2
    CONSTRUCTS WITH SEQUENCES FROM cdkn2a/b No data available
    MARKER RELATIONSHIPS
    cdkn2a/b Contained in: [BAC] CH211-145B13 (1), DKEY-123O10 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002660468 (1)
    Genomic GenBank:CT573245 (1) 196368 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8PZV6 (1) 129 aa
    Sequence Information (all 7)
    ORTHOLOGY for cdkn2a/b ( Chr: 1 )
    CITATIONS (28)