Gene
kif22
- ID
- ZDB-GENE-080204-34
- Name
- kinesin family member 22
- Symbol
- kif22 Nomenclature History
- Previous Names
-
- zKIF22 (1)
- zgc:171724
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have ATPase activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including central nervous system development; somitogenesis; and thigmotaxis. Predicted to localize to kinesin complex and microtubule. Is expressed in brain. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 2. Orthologous to human KIF22 (kinesin family member 22).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Blaker-Lee et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondyloepimetaphyseal dysplasia with joint laxity type 2 | Alliance | Spondyloepimetaphyseal dysplasia with joint laxity, type 2 | 603546 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Family | IPR026986 | Kinesin-like protein KIF22 (Kid) |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR010994 | RuvA domain 2-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Kinesin-like protein | Kinesin-like protein KIF22 (Kid) | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase | RuvA domain 2-like |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B7ZV80
|
634 | |||||||
|
UniProtKB:A8WFU8
|
634 | |||||||
|
UniProtKB:A0A0R4IAJ7
|
148 |
Interactions and Pathways
No data available
Plasmids
No data available