Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-080130-3
Gene Name: solute carrier family 12 (sodium/potassium/chloride transporter), member 1
Gene Symbol: slc12a1
Previous Name: nkcc2 (1)
Location: Chr: 18   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 14 figures from 5 publications
Wild-type Stages, Structures: Segmentation:26+ somites (22.0h-24.0h) to Larval:Day 6 (144.0h-168.0h)
  distal early tubule, mesonephric duct apical plasma membrane, pronephric distal early tubule
MUTANTS AND TARGETED KNOCKDOWNS No data available
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Bartter syndrome, type 1 601678
GENE ONTOLOGY
Ontology GO Term
Biological Process ion transport (more)
Cellular Component apical plasma membrane (more)
Molecular Function cation:chloride symporter activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002443 (1)
  • InterPro:IPR004841 (1)
  • InterPro:IPR004842 (1)
  • InterPro:IPR013612 (1)
  • Pfam:PF00324 (1)
  • Pfam:PF08403 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA slc12a1-001 (1) 2483
    slc12a1-002 (1) 763
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-slc12a (1)
    CONSTRUCTS WITH SEQUENCES FROM slc12a1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    slc12a1 Contained in: [BAC] CH73-34A12 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_002665297 (1) 2504 bp
    Genomic GenBank:CU498833 (1) 66872 bp
    Select Tool
    Polypeptide UniProtKB:F1R476 (1) 815 aa
    Sequence Clusters UniGene:156611 (1)
    Sequence Information (all 7)
    OTHER slc12a1 GENE PAGES
  • Gene:100329975 (1)
  • VEGA:OTTDARG00000032326 (1)
  • Ensembl(Zv9):ENSDARG00000059390 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish slc12a1 18  
    Human SLC12A1 15 (15q15-q21.1)
  • OMIM:600839
  • Gene:6557
  • Mouse Slc12a1 2 ( 61.23 cM)
  • MGI:103150
  • Gene:20495
  • Orthology Details
    CITATIONS (13)