ZFIN ID: ZDB-GENE-080130-3
Gene Name: solute carrier family 12 (sodium/potassium/chloride transporter), member 1
Gene Symbol: slc12a1
Previous Name: nkcc2 (1)
Location: Chr: 18   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 15 figures from 6 publications
Wild-type Stages, Structures: Segmentation:26+ somites (22.0h-24.0h) to Adult (90d-730d, breeding adult)
  distal early tubule, mesonephric duct apical plasma membrane, pronephric distal early tubule
MUTANTS AND TARGETED KNOCKDOWNS No data available
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Bartter syndrome, type 1 601678
GENE ONTOLOGY
Ontology GO Term
Biological Process ion transport (more)
Cellular Component apical plasma membrane (more)
Molecular Function cation:chloride symporter activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002443 (1)
  • InterPro:IPR004841 (1)
  • InterPro:IPR004842 (1)
  • InterPro:IPR013612 (1)
  • Pfam:PF00324 (1)
  • Pfam:PF08403 (1)
  •  Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-slc12a (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc12a1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    slc12a1 Contained in: [BAC] CH73-34A12 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009293403 (1) 2501 bp
    Genomic GenBank:CU498833 (1) 66872 bp
    Select Tool
    Polypeptide UniProtKB:F1R476 (1) 815 aa
    Sequence Clusters UniGene:156611 (1)
    Sequence Information (all 10)
    OTHER slc12a1 GENE PAGES
  • Gene:100329975 (1)
  • VEGA:OTTDARG00000032326 (1)
  • Ensembl(Zv9):ENSDARG00000059390 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish slc12a1 18  
    Human SLC12A1 15 (15q15-q21.1)
  • OMIM:600839
  • Gene:6557
  • Mouse Slc12a1 2 ( 61.23 cM)
  • MGI:103150
  • Gene:20495
  • Orthology Details
    CITATIONS (15)