Gene

il6st

ID
ZDB-GENE-080104-6
Name
interleukin 6 signal transducer
Symbol
il6st Nomenclature History
Previous Names
  • gp130 (1)
  • sb:eu844
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have cytokine binding activity and cytokine receptor activity. Involved in positive regulation of axon regeneration. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in several structures, including epidermis; immune system; liver; muscle; and sensory system. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; hyperandrogenism; and primary cutaneous amyloidosis. Orthologous to several human genes including IL6ST (interleukin 6 signal transducer).
Genome Resources
Note
None
Expression
All Expression Data
11 figures from 8 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il6st Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hyper IgE recurrent infection syndrome 4 Alliance Hyper-IgE recurrent infection syndrome 4, autosomal recessive 618523
Associated With il6st Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003961 Fibronectin type III
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold
UniProtKB:A8WH79 866
UniProtKB:C0SPC4 859
UniProtKB:F1RCZ2 859
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations