ZFIN ID: ZDB-GENE-080104-6
Gene Name: interleukin 6 signal transducer
Gene Symbol: il6st    Nomenclature History

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Previous Names: gp130 (1), sb:eu844

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have cytokine binding activity and cytokine receptor activity. Involved in positive regulation of axon regeneration. Predicted to localize to external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; hyperandrogenism; and primary cutaneous amyloidosis. Is expressed in several structures, including epidermis; immune system; liver; muscle; and sensory system. Orthologous to several human genes including IL6ST (interleukin 6 signal transducer).
Genome Resources: Alliance (1),  Gene:100006778 (1),  Ensembl(GRCz11):ENSDARG00000104693 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1462 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21662 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21663 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34843 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45394 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-il6st
    2
    CRISPR2-il6st
    2
    MO1-il6st N/A 3
    MO2-il6st N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH il6st HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hyper IgE recurrent infection syndrome 4 Alliance Hyper-IgE recurrent infection syndrome 4, autosomal recessive 618523
    DISEASE ASSOCIATED WITH il6st VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of axon regeneration (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cytokine binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA il6st-201 (1)    Ensembl 2601
    il6st-202 (1)    Ensembl 8300
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM il6st No data available
    MARKER RELATIONSHIPS
    il6st Contained in: [BAC] CH211-281K19, DKEYP-35F12 (1)
    il6st Encodes: [EST] eu844 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001113504 (1) 2601 nt
    Genomic GenBank:BX294128 (1) 160042 nt
    Select Tool
    Polypeptide UniProtKB:A8WH79 (1) 866 aa
    Sequence Information (all 18)
    ORTHOLOGY for il6st ( Chr: 10 )
    CITATIONS (35)