ZFIN ID: ZDB-GENE-071218-6
Gene Name: leucine-rich repeat kinase 2
Gene Symbol: lrrk2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have several functions, including Rho GTPase binding activity; SNARE binding activity; and protein kinase A binding activity. Predicted to be involved in several processes, including generation of neurons; regulation of autophagy; and regulation of signal transduction. Predicted to localize to several cellular components, including endoplasmic reticulum exit site; mitochondrial outer membrane; and perikaryon. Is expressed in gut; heart; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2).
Genome Resources: Alliance (1),  Gene:559366 (1),  Ensembl(GRCz11):ENSDARG00000006169 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa5114 Point Mutation Unknown Splice Site ENU
sa6813 Point Mutation Unknown Premature Stop ENU
sa6814 Point Mutation Unknown Splice Site ENU
sa8399 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38142 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf2079 Small Deletion Exon 44 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lrrk2 N/A 2
    MO2-lrrk2 N/A 2
    MO3-lrrk2 N/A 2
    MO4-lrrk2 N/A 1
    MO5-lrrk2 N/A 1
    MO6-lrrk2 N/A 1
    MO7-lrrk2 N/A 1
    DISEASE ASSOCIATED WITH lrrk2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Parkinson's disease 8 Alliance {Parkinson disease 8} 607060
    DISEASE ASSOCIATED WITH lrrk2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component axon (more)
    Molecular Function ATP binding (more)
    GO Terms (all 39)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lrrk2-201 (1)    Ensembl 9170
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-lrrk2 WB 1
    Ab2-lrrk2 monoclonal IgG Rabbit IHC, WB Abcam plc
    2
    PLASMIDS
    Addgene:40556
    CONSTRUCTS WITH SEQUENCES FROM lrrk2 No data available
    MARKER RELATIONSHIPS
    lrrk2 Contained in: [BAC] CH73-316L9 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001201456 (1) 9171 nt
    Genomic GenBank:CU855815 (1) 108410 nt
    Select Tool
    Polypeptide UniProtKB:D9IG64 (1) 2533 aa
    Sequence Information (all 14)
    ORTHOLOGY for lrrk2 ( Chr: 25 )
    CITATIONS (24)