Gene
lrrk2
- ID
- ZDB-GENE-071218-6
- Name
- leucine-rich repeat kinase 2
- Symbol
- lrrk2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and protein kinase activity. Predicted to be involved in protein phosphorylation. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; and cancer. Is expressed in gut; heart; muscle; nervous system; and pleuroperitoneal region. Orthologous to human LRRK2 (leucine rich repeat kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Parkinson's disease 8 | Alliance | {Parkinson disease 8} | 607060 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Parkinson's disease | lrrk2tud113/tud113 | standard conditions | Suzzi et al., 2021 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR020859 | Roc domain |
| Domain | IPR032171 | C-terminal of Roc (COR) domain |
| Family | IPR051420 | Ser/Thr Protein Kinases with Diverse Regulatory Roles |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
| Protein | Length | Ankyrin repeat-containing domain superfamily | Armadillo-like helical | Armadillo-type fold | C-terminal of Roc (COR) domain | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | P-loop containing nucleoside triphosphate hydrolase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Roc domain | Serine/threonine-protein kinase, active site | Ser/Thr Protein Kinases with Diverse Regulatory Roles | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B7E3
|
2660 | ||||||||||||||||
|
UniProtKB:A0A8M9PYE5
|
2175 | ||||||||||||||||
|
UniProtKB:A0A8M1P3G6
|
2556 |
Interactions and Pathways
No data available
Plasmids