Gene

atr

ID
ZDB-GENE-070912-458
Name
ATR serine/threonine kinase
Symbol
atr Nomenclature History
Previous Names
  • si:dkey-231j24.1
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in several processes, including determination of left/right symmetry; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of heart looping. Predicted to localize to nucleus. Is expressed in hindbrain neural rod; midbrain neural rod; optic vesicle; somite; and tail bud. Human ortholog(s) of this gene implicated in Seckel syndrome 1 and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Stiff et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Seckel syndrome 1 Alliance Seckel syndrome 1 210600
?Cutaneous telangiectasia and cancer syndrome, familial 614564
Associated With atr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR003151 PIK-related kinase, FAT
Domain IPR003152 FATC domain
Domain IPR012993 UME domain
Domain IPR014009 PIK-related kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Domain Details Per Protein
Protein Length Armadillo-type fold FATC domain Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site PIK-related kinase PIK-related kinase, FAT Protein kinase-like domain superfamily Tetratricopeptide-like helical domain superfamily UME domain
UniProtKB:F1QMM7 2635
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-atr polyclonal Rabbit
  • WB
Abcam plc
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations