ZFIN ID: ZDB-GENE-070912-26
Gene Name: contactin associated protein 2b
Gene Symbol: cntnap2b    Nomenclature History

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Previous Names: cntnap2 (1), si:ch211-120f16.4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to be involved in protein localization to juxtaparanode region of axon. Predicted to localize to integral component of membrane. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in several diseases, including Pitt-Hopkins syndrome; autism spectrum disorder (multiple); communication disorder (multiple); cortical dysplasia-focal epilepsy syndrome; and social phobia. Orthologous to human CNTNAP2 (contactin associated protein 2).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000074558 (2)
GENE EXPRESSION
All Expression Data: Fig. 4 from Xing et al., 2012
Wild-type Stages, Structures: Pharyngula:Prim-25 (36.0h-42.0h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa39945 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ya1955 Insertion Exon 4 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    ya2043 Small Deletion Exon 2 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cntnap2b
    2
    CRISPR2-cntnap2b
    2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cntnap2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cortical dysplasia-focal epilepsy syndrome Alliance Cortical dysplasia-focal epilepsy syndrome 610042
    Pitt-Hopkins like syndrome 1 610042
    {Autism susceptibility 15} 612100
    DISEASE ASSOCIATED WITH cntnap2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein localization to juxtaparanode region of axon (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cntnap2b-202 (1)    Ensembl 4126
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cntnap2 WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cntnap2b No data available
    MARKER RELATIONSHIPS
    cntnap2b Contained in: [BAC] CH211-120F16 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:BX927101 (1) 162145 nt
    Select Tool
    Polypeptide UniProtKB:B0S7S0 (1) 1315 aa
    Sequence Information (all 3)
    ORTHOLOGY for cntnap2b ( Chr: 2 )
    CITATIONS (21)