ZFIN ID: ZDB-GENE-070705-7
Gene Name: cyclin-dependent kinase inhibitor 1A
Gene Symbol: cdkn1a    Nomenclature History

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Previous Names: cip1, p21, waf1, si:ch1073-48m5.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have cyclin-dependent protein serine/threonine kinase inhibitor activity and kinase activity. Involved in aorta development; response to X-ray; and skeletal muscle cell differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in malignant glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Is expressed in several structures, including digestive system; hatching gland; male organism; nervous system; and pectoral fin bud. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A).
Genome Resources: Alliance (1),  Gene:100151416 (1),  Ensembl(GRCz11):ENSDARG00000076554 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014280Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014281Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022393Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022394Tg Transgenic Insertion Unknown Unknown DNA
    la028465Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cdkn1a N/A 6
    MO2-cdkn1a N/A 1
    DISEASE ASSOCIATED WITH cdkn1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cdkn1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process skeletal muscle tissue development (more)
    Cellular Component nucleus (more)
    Molecular Function cyclin-dependent protein serine/threonine kinase inhibitor activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdkn1a-201 (1)    Ensembl 1029
    cdkn1a-202 (1)    Ensembl 834
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    AB1-cdkn1a polyclonal Rabbit Cosmo Bio Co. LTD.
    1
    CONSTRUCTS WITH SEQUENCES FROM cdkn1a No data available
    MARKER RELATIONSHIPS
    cdkn1a Contained in: [Fosmid] CH1073-48M5 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001128420 (1)
    Genomic GenBank:CU062631 (1) 27912 nt
    Select Tool
    Polypeptide UniProtKB:A5WWG3 (1) 173 aa
    Sequence Information (all 12)
    ORTHOLOGY for cdkn1a ( Chr: 22 )
    CITATIONS (189)