ZFIN ID: ZDB-GENE-070705-19
Gene Name: chloride channel, voltage-sensitive 2a
Gene Symbol: clcn2a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: clc-2a (1), clcn2, si:ch211-117k11.1

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits chloride channel activity. Predicted to be involved in chloride transport. Localizes to cell junction. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000062427 (2)
Note: In communications with Alejandro Barrallo Gimeno, it was determined that this gene will be renamed clcn2a in his pending publication.
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH clcn2a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
idiopathic generalized epilepsy 11 Alliance {Epilepsy, idiopathic generalized, susceptibility to, 11} 607628
{Epilepsy, juvenile absence, susceptibility to, 2} 607628
{Epilepsy, juvenile myoclonic, susceptibility to, 8} 607628
primary hyperaldosteronism Alliance Hyperaldosteronism, familial, type II 605635
Leukoencephalopathy with ataxia 615651
DISEASE ASSOCIATED WITH clcn2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process chloride transport (more)
Cellular Component cell junction (more)
Molecular Function chloride channel activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA clcn2a-203 (1)    Ensembl 1970
ncRNA clcn2a-002 (1)    Ensembl 800
Browsers: EnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM clcn2a No data available
MARKER RELATIONSHIPS
clcn2a Contained in: [BAC] CH73-377B14 (1), CH211-117K11 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
Genomic GenBank:BX640595 (1) 121430 nt
Select Tool
Polypeptide UniProtKB:A5PMN6 (1) 656 aa
Sequence Information (all 3)
ORTHOLOGY for clcn2a ( Chr: 2 )
CITATIONS (17)