ZFIN ID: ZDB-GENE-070620-3
Gene Name: SIN3 transcription regulator family member Aa
Gene Symbol: sin3aa    Nomenclature History

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Previous Names: sin3a, zgc:162128

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to contribute to histone deacetylase activity. Predicted to be involved in histone deacetylation and negative regulation of transcription by RNA polymerase II. Predicted to localize to Sin3 complex. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A).
Genome Resources: Alliance (1),  Gene:563090 (1),  Ensembl(GRCz11):ENSDARG00000079716 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17441 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37997 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sin3aa N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH sin3aa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    chromosome 15q24 deletion syndrome Alliance Witteveen-Kolk syndrome 613406
    DISEASE ASSOCIATED WITH sin3aa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function transcription corepressor activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sin3aa-201 (1)    Ensembl 5189
    sin3aa-202 (1)    Ensembl 357
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sin3aa No data available
    MARKER RELATIONSHIPS
    sin3aa Contained in: [BAC] CH73-302F10 (1)
    sin3aa Encodes: [cDNA] MGC:162128 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001098180 (1) 5208 nt
    Genomic GenBank:CU207224 (1) 83543 nt
    Select Tool
    Polypeptide UniProtKB:A5D6S0 (1) 1276 aa
    Sequence Information (all 12)
    ORTHOLOGY for sin3aa ( Chr: 25 )
    CITATIONS (21)