Gene

itpr3

ID
ZDB-GENE-070605-1
Name
inositol 1,4,5-trisphosphate receptor, type 3
Symbol
itpr3 Nomenclature History
Previous Names
  • si:dkey-163f12.8
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have several functions, including calcium ion binding activity; inositol 1,4,5 trisphosphate binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in embryonic skeletal system development. Predicted to localize to endoplasmic reticulum; plasma membrane; and secretory granule membrane. Is expressed in brain; head; and pericardial region. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Henke et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With itpr3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type 1 diabetes mellitus Alliance {Diabetes, type 1, susceptibility to} 222100
Associated With itpr3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000699 RIH domain
Domain IPR005821 Ion transport domain
Domain IPR013662 RyR/IP3R Homology associated domain
Domain IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
Domain IPR016093 MIR motif
Family IPR000493 Inositol 1,4,5-trisphosphate receptor
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR035910 RyR/IP3 receptor binding core, RIH domain superfamily
Homologous_superfamily IPR036300 Mir domain superfamily
Domain Details Per Protein
Protein Length Armadillo-type fold Inositol 1,4,5-trisphosphate receptor Inositol 1,4,5-trisphosphate/ryanodine receptor Ion transport domain Mir domain superfamily MIR motif RIH domain RyR/IP3 receptor binding core, RIH domain superfamily RyR/IP3R Homology associated domain
UniProtKB:F1QLD3 232
UniProtKB:A8WG42 226
UniProtKB:F1Q5E3 332
UniProtKB:F1R1L5 2293
UniProtKB:A0A0R4IH08 2634
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations