ZFIN ID: ZDB-GENE-070605-1
Gene Name: inositol 1,4,5-trisphosphate receptor, type 3
Gene Symbol: itpr3    Nomenclature History

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Previous Name: si:dkey-163f12.8

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have anion binding activity; calcium ion binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in embryonic skeletal system development. Predicted to localize to several cellular components, including endoplasmic reticulum membrane; sarcoplasmic reticulum; and secretory granule membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Is expressed in brain; head; and pericardial region. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).
Genome Resources: Alliance (1),  Gene:794666 (1),  Ensembl(GRCz11):ENSDARG00000061741 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dmh21 Point Mutation Unknown Nonsynonymous ENU
dmh30 Point Mutation Unknown Missense
sa11400 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13385 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14415 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15369 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17468 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21271 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21272 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21273 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21274 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21275 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41183 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41184 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41185 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41186 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45319 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-itpr3 N/A 1
    MO2-itpr3 N/A 1
    PHENOTYPE
    Data: Fig. 4 from Henke et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH itpr3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    type 1 diabetes mellitus Alliance {Diabetes, type 1, susceptibility to} 222100
    DISEASE ASSOCIATED WITH itpr3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic skeletal system development (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function calcium channel activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itpr3-201 (1)    Ensembl 7368
    itpr3-202 (1)    Ensembl 1319
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itpr3 No data available
    MARKER RELATIONSHIPS
    itpr3 Contained in: [BAC] DKEY-163F12 (1) (order this), RP71-1G9
    itpr3 Encodes: [cDNA] MGC:172178 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001128269 (1) 1141 nt
    Genomic GenBank:BX784023 (1) 231254 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IH08 (1) 2634 aa
    Sequence Information (all 21)
    ORTHOLOGY for itpr3 ( Chr: 8 )
    CITATIONS (26)