ZFIN ID: ZDB-GENE-070605-1
Gene Name: inositol 1,4,5-trisphosphate receptor, type 3
Gene Symbol: itpr3
Sequence Ontology ID : SO:0000704

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: si:dkey-163f12.8

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 8 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have several functions, including anion binding activity, calcium ion binding activity, and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; involved in embryonic  ...
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dmh21 Point Mutation Unknown Nonsynonymous ENU
dmh30 Point Mutation Unknown Missense
sa11400 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13385 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14415 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15369 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17468 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21271 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21272 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21273 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21274 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21275 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41183 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41184 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41185 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41186 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45319 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: Fig. 4 from Henke et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH itpr3 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    type 1 diabetes mellitus {Diabetes, type 1, susceptibility to} 222100
    DISEASE ASSOCIATED WITH itpr3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic skeletal system development (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function calcium channel activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000493 (1)
  • InterPro:IPR000699 (1)
  • InterPro:IPR005821 (1)
  • InterPro:IPR013662 (1)
  • InterPro:IPR014821 (1)
  • InterPro:IPR015925 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR016093 (1)
  • InterPro:IPR035910 (1)
  • InterPro:IPR036300 (1)
  • PROSITE:PS50919 (1)
  • Pfam:PF00520 (1)
  • Pfam:PF01365 (1)
  • Pfam:PF02815 (1)
  • Pfam:PF08454 (1)
  • Pfam:PF08709 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA itpr3-201 (1) 7368
    itpr3-202 (1) 1319
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM itpr3 No data available
    MARKER RELATIONSHIPS
    itpr3Contained in: [BAC] DKEY-163F12 (1) (order this), RP71-1G9 (order this)
    itpr3Encodes: [cDNA] MGC:172178 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128269 (1) 1141bp
    Genomic GenBank:BX784023 (1) 231254bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IH08 (1) 2634aa
    Sequence Clusters UniGene:158518 (1)
    Sequence Information (all 22)
    OTHER itpr3 GENE PAGES
  • Alliance (1)
  • Gene:794666 (1)
  • VEGA:OTTDARG00000026569 (1)
  • ORTHOLOGY for itpr3 (Chr: 8)
    CITATIONS (23)