Gene
cerkl
- ID
- ZDB-GENE-070410-38
- Name
- ceramide kinase-like
- Symbol
- cerkl Nomenclature History
- Previous Names
-
- zgc:162213
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have NAD+ kinase activity. Involved in several processes, including negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; regulation of apoptotic cell clearance; and retina layer formation. Localizes to cytosol and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 26. Is expressed in several structures, including eye; gill; heart; kidney; and optic cup. Orthologous to human CERKL (ceramide kinase like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
retinitis pigmentosa 26 | Alliance | Retinitis pigmentosa 26 | 608380 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Diacylglycerol kinase, catalytic domain | Inorganic polyphosphate/ATP-NAD kinase, N-terminal | NAD kinase/diacylglycerol kinase-like domain superfamily |
---|---|---|---|---|
UniProtKB:A4QNW6
|
577 |
Interactions and Pathways
No data available
Plasmids
No data available