Gene

cerkl

ID
ZDB-GENE-070410-38
Name
ceramide kinase-like
Symbol
cerkl Nomenclature History
Previous Names
  • zgc:162213
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have NAD+ kinase activity. Involved in several processes, including negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; regulation of apoptotic cell clearance; and retina layer formation. Localizes to cytosol and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 26. Is expressed in several structures, including eye; gill; heart; kidney; and optic cup. Orthologous to human CERKL (ceramide kinase like).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cerkl Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
retinitis pigmentosa 26 Alliance Retinitis pigmentosa 26 608380
Associated With cerkl Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001206 Diacylglycerol kinase, catalytic domain
Homologous_superfamily IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
Homologous_superfamily IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
Domain Details Per Protein
Protein Length Diacylglycerol kinase, catalytic domain Inorganic polyphosphate/ATP-NAD kinase, N-terminal NAD kinase/diacylglycerol kinase-like domain superfamily
UniProtKB:A4QNW6 577
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cerkl polyclonal IgG Rabbit
  • IHC
Abcam plc
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations