ZFIN ID: ZDB-GENE-070117-2066
Gene Name: fleer
Gene Symbol: flr    Nomenclature History

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Previous Names: DYF-1 (1), IFT70 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits tubulin-glycine ligase activity. Involved in several processes, including cilium organization; opsin transport; and protein polyglutamylation. Localizes to axonemal microtubule and motile cilium. Is expressed in Kupffer's vesicle; lateral mesoderm; nervous system; and pronephros. Orthologous to several human genes including TTC30B (tetratricopeptide repeat domain 30B).
Genome Resources: Alliance (1),  Gene:797829 (1),  Ensembl(GRCz11):ENSDARG00000038024 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 2 publications
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028891Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m477 Point Mutation Unknown Premature Stop ENU
    sa40077 Point Mutation Unknown Missense, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tpl19Gt Transgenic Insertion Intron 1 Unknown DNA
    tpl19RGt Transgenic Insertion Unknown Unknown DNA
    tpl141Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
    zf359 Point Mutation Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-flr 1
    MO1-flr N/A 2
    MO2-flr N/A 1
    DISEASE ASSOCIATED WITH flr HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH flr VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cilium assembly (more)
    Cellular Component axonemal microtubule (more)
    Molecular Function tubulin-glycine ligase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript flr-202 (1)    Ensembl 2015
    mRNA flr-201 (1)    Ensembl 2559
    ncRNA flr-003 (1)    Ensembl 575
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM flr No data available
    MARKER RELATIONSHIPS
    flr Contained in: [BAC] CH211-76L23 (1)
    flr Encodes: [cDNA] MGC:195339 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001104649 (1) 2556 nt
    Genomic GenBank:BX510989 (1) 169229 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q8D1 (1) 667 aa
    Sequence Information (all 23)
    ORTHOLOGY for flr ( Chr: 3 )
    CITATIONS (41)