ZFIN ID: ZDB-GENE-070112-1732
Gene Name: epithelial splicing regulatory protein 1
Gene Symbol: esrp1    Nomenclature History

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Previous Names: rbm35a, wu:fi28a07, zgc:154050

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have mRNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to localize to nucleoplasm. Is expressed in several structures, including digestive system; ectoderm; epidermis; median fin fold; and tail bud. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Orthologous to human ESRP1 (epithelial splicing regulatory protein 1).
Genome Resources: Alliance (1),  Gene:560190 (1),  Ensembl(GRCz11):ENSDARG00000011245 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
crg1 Indel Exon 1 Cryptic Donor Splice Site CRISPR
la012899Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-esrp1
    1
    CRISPR2-esrp1 1
    MO1-esrp1 N/A 1
    PHENOTYPE
    Data: Fig. S3 from Burguera et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH esrp1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive nonsyndromic deafness 109 Alliance ?Deafness, autosomal recessive 109 618013
    DISEASE ASSOCIATED WITH esrp1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of RNA splicing (more)
    Cellular Component nucleus (more)
    Molecular Function mRNA binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA esrp1-201 (1)    Ensembl 3669
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-esrp1 WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM esrp1 No data available
    MARKER RELATIONSHIPS
    esrp1 Contained in: [BAC] CH211-79L20, DKEY-218I12 (1) (order this)
    esrp1 Encodes: [EST] fi28a07
    [cDNA] MGC:154050 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080576 (1) 3661 nt
    Genomic GenBank:BX511010 (1) 156317 nt
    Select Tool
    Polypeptide UniProtKB:A1L1G1 (1) 714 aa
    Sequence Information (all 15)
    ORTHOLOGY for esrp1 ( Chr: 16 )
    CITATIONS (28)