ZFIN ID: ZDB-GENE-061207-9
Gene Name: transmembrane inner ear
Gene Symbol: tmie    Nomenclature History

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Previous Name: si:ch211-163f10.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Involved in posterior lateral line neuromast primordium migration; sensory organ development; and sensory perception of sound. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 6 and sensorineural hearing loss. Is expressed in brain and otic vesicle. Orthologous to human TMIE (transmembrane inner ear).
Genome Resources: Alliance (1),  Gene:555430 (1),  Ensembl(GRCz11):ENSDARG00000069423 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014848Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ru1000 Indel Unknown Unknown
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t26171 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tmie
    1
    CRISPR2-tmie
    2
    CRISPR3-tmie
    3
    MO1-tmie N/A 1
    MO2-tmie N/A 1
    MO3-tmie N/A 1
    DISEASE ASSOCIATED WITH tmie HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive nonsyndromic deafness 6 Alliance Deafness, autosomal recessive 6 600971
    DISEASE ASSOCIATED WITH tmie VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process auditory receptor cell stereocilium organization (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tmie-201 (1)    Ensembl 827
    tmie-202 (1)    Ensembl 696
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tmie
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(myo6b:gria2a-tmie-2a-nls-mcherry) myo6b 2Agria2amCherryNLStmie Danio rerio 1 1
    tg(myo6b:gria2a-tmie-egfp) myo6b EGFPgria2atmie Danio rerio 1 1
    tg(myo6b:tmie-2a-nls-mcherry) myo6b 2AmCherryNLStmie Danio rerio 1 1
    tg(myo6b:tmie-egfp) myo6b EGFPtmie Danio rerio 1 1
    Tg(myo6b:tmie-HA) myo6b HAtmie Danio rerio 1 1
    tg(myo6b:tmie-hsa.cd8a-2a-nls-mcherry) myo6b 2AmCherryNLStmie Danio rerio 1 1
    tg(myo6b:tmie-hsa.cd8a-egfp) myo6b EGFPtmie Danio rerio 1 1
    MARKER RELATIONSHIPS
    tmie Contained in: [BAC] CH73-264D1 (1), CH211-163F10 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001170647 (1)
    Genomic GenBank:AL929518 (1) 162473 nt
    Select Tool
    Polypeptide UniProtKB:D2ITC5 (1) 231 aa
    Sequence Information (all 17)
    ORTHOLOGY for tmie ( Chr: 2 )
    CITATIONS (34)