ZFIN ID: ZDB-GENE-061110-61
Gene Name: OCRL inositol polyphosphate-5-phosphatase
Gene Symbol: ocrl    Nomenclature History

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Previous Names: OCRL1 (1), wu:fi09g03, zgc:152864

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in several processes, including animal organ development; melanosome transport; and phosphatidylinositol dephosphorylation. Predicted to localize to the cytoplasm and membrane. Used to study oculocerebrorenal syndrome. Human ortholog(s) of this gene implicated in Dent disease and oculocerebrorenal syndrome. Is expressed in several structures, including heart; immature eye; liver; nervous system; and pleuroperitoneal region. Orthologous to human OCRL (OCRL inositol polyphosphate-5-phosphatase).
Genome Resources: Alliance (1),  Gene:777716 (1),  Ensembl(GRCz11):ENSDARG00000078106 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11582 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17235 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22515 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24963 Point Mutation Unknown Premature Stop ENU
    umc5Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ocrl N/A 2
    MO2-ocrl N/A 4
    MO3-ocrl N/A 1
    MO4-ocrl N/A 1
    DISEASE ASSOCIATED WITH ocrl HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Dent disease Alliance Dent disease 2 300555
    oculocerebrorenal syndrome Alliance Lowe syndrome 309000
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endocytosis (more)
    Cellular Component cytoplasm (more)
    Molecular Function phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000198 Rho GTPase-activating protein domain
    Domain IPR000300 Inositol polyphosphate-related phosphatase
    Domain IPR005135 Endonuclease/exonuclease/phosphatase
    Domain IPR031995 Inositol polyphosphate 5-phosphatase, clathrin binding domain
    Domain IPR037787 OCRL1, PH domain
    Domain IPR037793 OCRL1/INPP5B, INPP5c domain
    Homologous_superfamily IPR008936 Rho GTPase activation protein
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR036691 Endonuclease/exonuclease/phosphatase superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ocrl-201 (1)    Ensembl 5875
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ocrl monoclonal IgG1 Mouse WB UC Davis/NIH NeuroMab Facility
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ocrl No data available
    MARKER RELATIONSHIPS
    ocrl Contained in: [BAC] CH73-335M24 (1), DKEY-76I15 (1) (order this)
    ocrl Encodes: [EST] fi09g03
    [cDNA] MGC:152864 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077764 (1) 2984 nt
    Genomic GenBank:FP016208 (1) 127761 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IPY6 (1) 961 aa
    Sequence Information (all 18)
    ORTHOLOGY for ocrl ( Chr: 14 )
    CITATIONS (27)