ZFIN ID: ZDB-GENE-061110-61
Gene Name: OCRL inositol polyphosphate-5-phosphatase
Gene Symbol: ocrl    Nomenclature History

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Previous Names: OCRL1 (1), wu:fi09g03, zgc:152864

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in several processes, including animal organ development; melanosome transport; and phosphatidylinositol dephosphorylation. Predicted to localize to cytoplasm and membrane. Is expressed in several structures, including heart; immature eye; liver; nervous system; and pleuroperitoneal region. Used to study oculocerebrorenal syndrome. Human ortholog(s) of this gene implicated in Dent disease and oculocerebrorenal syndrome. Orthologous to human OCRL (OCRL inositol polyphosphate-5-phosphatase).
Genome Resources: Alliance (1),  Gene:777716 (1),  Ensembl(GRCz11):ENSDARG00000078106 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11582 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17235 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22515 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24963 Point Mutation Unknown Premature Stop ENU
    umc5Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ocrl N/A 2
    MO2-ocrl N/A 4
    MO3-ocrl N/A 1
    MO4-ocrl N/A 1
    DISEASE ASSOCIATED WITH ocrl HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Dent disease Alliance Dent disease 2 300555
    oculocerebrorenal syndrome Alliance Lowe syndrome 309000
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endocytosis (more)
    Cellular Component cytoplasm (more)
    Molecular Function phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ocrl-201 (1)    Ensembl 5875
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ocrl monoclonal IgG1 Mouse WB UC Davis/NIH NeuroMab Facility
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ocrl No data available
    MARKER RELATIONSHIPS
    ocrl Contained in: [BAC] CH73-335M24 (1), DKEY-76I15 (1) (order this)
    ocrl Encodes: [EST] fi09g03
    [cDNA] MGC:152864 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077764 (1) 2984 nt
    Genomic GenBank:FP016208 (1) 127761 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IPY6 (1) 961 aa
    Sequence Information (all 18)
    ORTHOLOGY for ocrl ( Chr: 14 )
    CITATIONS (28)