Gene

ece1

ID
ZDB-GENE-061110-100
Name
endothelin converting enzyme 1
Symbol
ece1 Nomenclature History
Previous Names
  • fd11b07
  • wu:fd11b07
  • zgc:154079
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have metal ion binding activity and metalloendopeptidase activity. Involved in embryonic viscerocranium morphogenesis. Predicted to localize to integral component of membrane and plasma membrane. Is expressed in cardiovascular system; fin bud; hindbrain; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; essential hypertension; and hypertension. Orthologous to human ECE1 (endothelin converting enzyme 1).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Iklé et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ece1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
essential hypertension Alliance {Hypertension, essential, susceptibility to} 145500
?Hirschsprung disease, cardiac defects, and autonomic dysfunction 613870
Associated With ece1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR008753 Peptidase M13, N-terminal domain
Domain IPR018497 Peptidase M13, C-terminal domain
Family IPR000718 Peptidase M13
Family IPR029734 Endothelin-converting enzyme 1
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR042089 Peptidase M13, domain 2
Domain Details Per Protein
Protein Length Endothelin-converting enzyme 1 Metallopeptidase, catalytic domain superfamily Peptidase M13 Peptidase M13, C-terminal domain Peptidase M13, domain 2 Peptidase M13, N-terminal domain
UniProtKB:E9QDP9 142
UniProtKB:F1QE95 752
UniProtKB:A0JMP1 752
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations