ZFIN Gene: ece1

ZFIN ID: ZDB-GENE-061110-100

ZFIN ID: ZDB-GENE-061110-100

Gene Name:

endothelin converting enzyme 1

Gene Symbol:

ece1

Sequence Ontology ID :

SO:0001217

Previous Names:

fd11b07, wu:fd11b07, zgc:154079

Location:

Chr: 11 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have metalloendopeptidase activity. Involved in embryonic viscerocranium morphogenesis. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene ...

GENE EXPRESSION
All Expression Data:	2 figures from Iklé et al., 2017
Wild-type Stages, Structures:	Pharyngula:Prim-5 (24.0h-30.0h) to Hatching:Long-pec (48.0h-60.0h)
	dorsal aorta fin bud heart heart tube hindbrain intersegmental vessel pharyngeal arch somite whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa5844	Point Mutation	Unknown	Splice Site	ENU
sa9969	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa11183	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa11416	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa21930	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35103	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35104	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

MO1-ece1 (1)
MO2-ece1 (1)

PHENOTYPE

Data:	2 figures from Iklé et al., 2017
Observed in:	basihyal cartilage ceratobranchial cartilage ceratohyal cartilage cranial cartilage hyosymplectic cartilage Meckel's cartilage palatoquadrate cartilage pharyngeal arch 1 pharyngeal arch 2

DISEASE ASSOCIATED WITH ece1 HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
essential hypertension	{Hypertension, essential, susceptibility to}	145500
	?Hirschsprung disease, cardiac defects, and autonomic dysfunction	613870

DISEASE ASSOCIATED WITH ece1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	embryonic viscerocranium morphogenesis (more)
Cellular Component	integral component of membrane (more)
Molecular Function	metalloendopeptidase activity (more)

GO Terms (all 6)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000718 (1) InterPro:IPR008753 (1) InterPro:IPR018497 (1) InterPro:IPR024079 (1) InterPro:IPR029734 (1) InterPro:IPR042089 (1)	Pfam:PF01431 (1) Pfam:PF05649 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	ece1-201 (1)	3293	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	ece1-202 (1)	525	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION No description available

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM ece1 No data available

MARKER RELATIONSHIPS

ece1 Contained in:	[BAC] CH211-198P5 (1) (order this), CH211-220M17 (1) (order this)
ece1 Encodes:	[EST] fd11b07 [cDNA] MGC:154079 (1) (order this), MGC:192976 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001077792 (1)	2580 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX248318 (1)	194209 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0JMP1 (1)	752 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:79706 (1)

Sequence Information (all 18)

OTHER ece1 GENE PAGES

Alliance (1)

Gene:777750 (1)

VEGA:OTTDARG00000027719 (1)

Ensembl(GRCz11):ENSDARG00000061737 (2)

ORTHOLOGY for ece1 ( Chr: 11 )

CITATIONS (18)

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