| ZFIN ID: ZDB-GENE-061110-100 |
| Gene Name: | endothelin converting enzyme 1 | |||||||||||||
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| Gene Symbol: | ece1 Nomenclature History |
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| Previous Names: | fd11b07, wu:fd11b07, zgc:154079 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 11 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have metalloendopeptidase activity. Involved in embryonic viscerocranium morphogenesis. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; congestive heart failure; coronary artery disease; essential hypertension; and hypertension. Is expressed in cardiovascular system; fin bud; hindbrain; pharyngeal arch; and somite. Orthologous to human ECE1 (endothelin converting enzyme 1). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:777750 (1), Ensembl(GRCz11):ENSDARG00000061737 (2) | |||||||||||||
| All Expression Data: | 2 figures from Iklé et al., 2017 |
| Wild-type Stages, Structures: | Pharyngula:Prim-5 (24.0h-30.0h) to Hatching:Long-pec (48.0h-60.0h) |
| Curated Microarray Expression: | GEO (1) |
| Data: | 2 figures from Iklé et al., 2017 |
| Observed in: |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential hypertension | Alliance | {Hypertension, essential, susceptibility to} | 145500 |
| ?Hirschsprung disease, cardiac defects, and autonomic dysfunction | 613870 |
| Ontology | GO Term |
|---|---|
| Biological Process | embryonic viscerocranium morphogenesis (more) |
| Cellular Component | integral component of membrane (more) |
| Molecular Function | metalloendopeptidase activity (more) |
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| Type | Name | Length (nt) | Analysis | |
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| mRNA |
ece1-201
(1)
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3293 |
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ece1-202
(1)
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525 |
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
| ece1 Contained in: | [BAC] CH211-198P5 (1) (order this), CH211-220M17 (1) (order this) |
| ece1 Encodes: |
[EST]
fd11b07
[cDNA] MGC:154079 (1) (order this), MGC:192976 (1) (order this) |
| Type | Accession # | Length (bp/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001077792 (1) | 2580 bp |
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| Genomic | GenBank:BX248318 (1) | 194209 bp | |
| Polypeptide | UniProtKB:A0JMP1 (1) | 752 aa |
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| Sequence Clusters | UniGene:79706 (1) |
