Gene
ece1
- ID
- ZDB-GENE-061110-100
- Name
- endothelin converting enzyme 1
- Symbol
- ece1 Nomenclature History
- Previous Names
-
- fd11b07
- wu:fd11b07
- zgc:154079
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have metal ion binding activity and metalloendopeptidase activity. Involved in embryonic viscerocranium morphogenesis. Predicted to localize to integral component of membrane and plasma membrane. Is expressed in cardiovascular system; fin bud; hindbrain; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; essential hypertension; and hypertension. Orthologous to human ECE1 (endothelin converting enzyme 1).
- Genome Resources
- Note
- None
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Iklé et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential hypertension | Alliance | {Hypertension, essential, susceptibility to} | 145500 |
| ?Hirschsprung disease, cardiac defects, and autonomic dysfunction | 613870 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR008753 | Peptidase M13, N-terminal domain |
| Domain | IPR018497 | Peptidase M13, C-terminal domain |
| Family | IPR000718 | Peptidase M13 |
| Family | IPR029734 | Endothelin-converting enzyme 1 |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR042089 | Peptidase M13, domain 2 |
Domain Details Per Protein
| Protein | Length | Endothelin-converting enzyme 1 | Metallopeptidase, catalytic domain superfamily | Peptidase M13 | Peptidase M13, C-terminal domain | Peptidase M13, domain 2 | Peptidase M13, N-terminal domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:E9QDP9
|
142 | ||||||
|
UniProtKB:F1QE95
|
752 | ||||||
|
UniProtKB:A0JMP1
|
752 |
Interactions and Pathways
No data available
Plasmids
No data available