Gene

nyx

ID

ZDB-GENE-061026-3

Name

nyctalopin

Symbol

nyx Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Acts upstream of or within optokinetic behavior and visual perception. Is expressed in retinal ganglion cell layer; retinal inner nuclear layer; retinal inner plexiform layer; and retinal outer plexiform layer. Used to study congenital stationary night blindness and congenital stationary night blindness 1A. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1A and night blindness. Orthologous to human NYX (nyctalopin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from Bahadori et al., 2006

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Peachey et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nyx Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital stationary night blindness 1A	Alliance	Night blindness, congenital stationary (complete), 1A, X-linked	310500

Associated With nyx Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital stationary night blindness	WT + MO1-nyx	standard conditions	Bahadori et al., 2006
congenital stationary night blindness 1A	WT + MO1-nyx	standard conditions	Peachey et al., 2012

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000483	Cysteine-rich flanking region, C-terminal
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype