| ZFIN ID: ZDB-GENE-061026-3 |
| Gene Name: | nyctalopin | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol: | nyx Nomenclature History |
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 9 Mapping Details/Browsers | |||||||||||||
| Description: | Involved in optokinetic behavior and visual perception. Is expressed in retinal ganglion cell layer; retinal inner nuclear layer; retinal inner plexiform layer; and retinal outer plexiform layer. Used to study congenital stationary night blindness and congenital stationary night blindness 1A. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1A and night blindness. Orthologous to human NYX (nyctalopin). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:568821 (1), Ensembl(GRCz11):ENSDARG00000061791 (2) | |||||||||||||
| All Expression Data: | 5 figures from Bahadori et al., 2006 |
| Wild-type Stages, Structures: | Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| sa31731 | Point Mutation | Unknown | Premature Stop | ENU |
|
PHENOTYPE
| Data: | Fig. 4 from Peachey et al., 2012 |
| Observed in: |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital stationary night blindness 1A | Alliance | Night blindness, congenital stationary (complete), 1A, X-linked | 310500 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital stationary night blindness | WT + MO1-nyx | standard conditions | Bahadori et al., 2006 |
| congenital stationary night blindness 1A | WT + MO1-nyx | standard conditions | Peachey et al., 2012 |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
nyx-201
(1)
|
2226 |
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM nyx
| Construct | Regulatory Regions | Coding Sequences | Species | Tg Lines | Publications |
|---|---|---|---|---|---|
| Tg(nyx:GAL4-VP16) | nyx | GAL4, VP16 | Danio rerio | 1 | 16 |
MARKER RELATIONSHIPS
| nyx Contained in: | [BAC] DKEY-216E24 (1) (order this) |
| nyx Encodes: | [cDNA] MGC:194863 (1), MGC:194882 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001077617 (1) | 1410 nt |
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| Genomic | GenBank:BX545856 (1) | 209295 nt | Blast at MegaBLAST |
| Polypeptide | UniProtKB:Q00P20 (1) | 469 aa |
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ORTHOLOGY for nyx (
Chr:
9
)
CITATIONS (20)