Gene

spint2

ID
ZDB-GENE-061013-323
Name
serine peptidase inhibitor, Kunitz type, 2
Symbol
spint2 Nomenclature History
Previous Names
  • fb52h04
  • fe24a06
  • wu:fb52h04
  • wu:fe24a06
  • zgc:153795
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase inhibitor activity. Predicted to localize to extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to human SPINT2 (serine peptidase inhibitor, Kunitz type 2).
Genome Resources
Note
None
Expression
All Expression Data
Fig. S3 from Wang et al., 2017
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With spint2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital secretory sodium diarrhea 3 Alliance Diarrhea 3, secretory sodium, congenital, syndromic 270420
Associated With spint2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
Domain IPR002223 Pancreatic trypsin inhibitor Kunitz domain
Domain IPR011106 Seven cysteines, N-terminal
Domain IPR013980 MANSC domain
Homologous_superfamily IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
Domain Details Per Protein
Protein Length MANSC domain Pancreatic trypsin inhibitor Kunitz domain Pancreatic trypsin inhibitor Kunitz domain superfamily Proteinase inhibitor I2, Kunitz, conserved site Seven cysteines, N-terminal
UniProtKB:Q08BG0 431
UniProtKB:R4GEK7 265
UniProtKB:F1QEV7 431
UniProtKB:Q1RLQ3 380
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations