ZFIN is now using GRCz12tu for Genomic Data
Gene
grk4
- ID
- ZDB-GENE-060929-1198
- Name
- G protein-coupled receptor kinase 4
- Symbol
- grk4 Nomenclature History
- Previous Names
-
- GRK5 (1)
- zgc:153020
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein kinase activity. Acts upstream of or within cilium organization; pronephros development; and symbiont-mediated activation of host NF-kappaB cascade. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; nervous system; notochord; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Gerhards et al., 2023
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Gerhards et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR016137 | RGS domain |
| Family | IPR000239 | GPCR kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036305 | RGS domain superfamily |
| Homologous_superfamily | IPR044926 | RGS, subdomain 2 |
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | GPCR kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RGS domain | RGS domain superfamily | RGS, subdomain 2 | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q08CJ6 | InterPro | 573 | |||||||||
| UniProtKB:A0A8M3BE02 | InterPro | 579 | |||||||||
| UniProtKB:A0AB13A7J2 | InterPro | 579 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers