Gene

grk4

ID
ZDB-GENE-060929-1198
Name
G protein-coupled receptor kinase 4
Symbol
grk4 Nomenclature History
Previous Names
  • GRK5 (1)
  • zgc:153020
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and G protein-coupled receptor kinase activity. Involved in induction by symbiont of host I-kappaB kinase/NF-kappaB cascade. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grk4 Human Ortholog
No data available
Associated With grk4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR016137 RGS domain
Family IPR000239 GPCR kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036305 RGS domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal GPCR kinase Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily RGS domain RGS domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q08CJ6 573
UniProtKB:A0A0R4IXX5 140
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations