ZFIN ID: ZDB-GENE-060929-1198
Gene Name: G protein-coupled receptor kinase 4
Gene Symbol: grk4    Nomenclature History

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Previous Names: GRK5 (1), zgc:153020

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and G protein-coupled receptor kinase activity. Involved in induction by symbiont of host I-kappaB kinase/NF-kappaB cascade. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4).
Genome Resources: Alliance (1),  Gene:560761 (1),  Ensembl(GRCz11):ENSDARG00000070448 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013559Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39565 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko252a Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko252b Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-grk4 1
    MO1-grk4 N/A 1
    MO2-grk4 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH grk4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH grk4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process induction by symbiont of host I-kappaB kinase/NF-kappaB cascade (more)
    Cellular Component cellular_component (more)
    Molecular Function ATP binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA grk4-202 (1)    Ensembl 7227
    grk4-203 (1)    Ensembl 860
    ncRNA grk4-002 (1)    Ensembl 1334
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM grk4 No data available
    MARKER RELATIONSHIPS
    grk4 Contained in: [BAC] DKEY-21J8 (1) (order this), DKEY-58J15 (1) (order this)
    grk4 Encodes: [cDNA] MGC:153020 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001079986 (1) 2596 nt
    Genomic GenBank:BX569778 (1) 255895 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q08CJ6 (1) 573 aa
    Sequence Information (all 16)
    ORTHOLOGY for grk4 ( Chr: 1 )
    CITATIONS (24)