ZFIN ID: ZDB-GENE-060825-45
Gene Name: ATPase, Cu++ transporting, alpha polypeptide
Gene Symbol: atp7a
Sequence Ontology ID : SO:0000704

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Previous Names: cal, calamity, wu:fc43e01, zgc:153422, zgc:158633

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(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 5 publications
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Adult (90d-730d, breeding adult)
  gill, gut, liver, neural tube (all 6) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
gw71 Point Mutation Unknown Unknown ENU
j246 Point Mutation Unknown Splice Site, Inframe Deletion ENU
sa17337 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa22467 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35686 Point Mutation Unknown Splice Site ENU
    sa35687 Point Mutation Unknown Premature Stop ENU
    sa38992 Point Mutation Unknown Premature Stop ENU
    sa42389 Point Mutation Unknown Splice Site ENU
    vu69 Point Mutation Intron 8 Cryptic Acceptor Splice Site, Frameshift Truncation ENU
    Targeting reagents: MO1-atp7a (1), MO2-atp7a (1), MO3-atp7a (1)
    PHENOTYPE
    Data: 5 figures from 3 publications
    Observed in: blood, fourth ventricle, heart, melanocyte (all 11) expand
    DISEASE ASSOCIATED WITH atp7a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Menkes disease Menkes disease 309400
    Occipital horn syndrome 304150
    Spinal muscular atrophy, distal, X-linked 3 300489
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to copper ion (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cation-transporting ATPase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001757 (1)
  • InterPro:IPR006121 (1)
  • InterPro:IPR006122 (1)
  • InterPro:IPR008250 (1)
  • InterPro:IPR017969 (1)
  • InterPro:IPR018303 (1)
  • InterPro:IPR023214 (1)
  • InterPro:IPR023298 (1)
  • InterPro:IPR023299 (1)
  • InterPro:IPR027256 (1)
  • PROSITE:PS00154 (1)
  • PROSITE:PS01047 (1)
  • PROSITE:PS50846 (1)
  • Pfam:PF00122 (1)
  • Pfam:PF00403 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA atp7a-001 (1) 7709
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Ab1-atp7a (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM atp7a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    atp7aContained in: [BAC] CH211-107M4 (1) (order this), CH211-215G18 (1) (order this), DKEY-179C7 (1) (order this)
    atp7aEncodes: [EST] fc43e01 (1)
    [cDNA] MGC:153422 (1) (order this), MGC:158633 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001042720 (1) 4449bp
    Genomic GenBank:BX120008 (1) 221928bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q5B3 (1) 1500aa
    Sequence Clusters UniGene:134748 (1)
    Sequence Information (all 25)
    OTHER atp7a GENE PAGES
  • Gene:564924 (1)
  • VEGA:OTTDARG00000020943 (1)
  • Ensembl(GRCz10):ENSDARG00000003699 (1)
  • ORTHOLOGY for atp7a (Chr: 14)
    CITATIONS (26)