ZFIN ID: ZDB-GENE-060531-23
Gene Name: nuclear receptor subfamily 3, group C, member 2
Gene Symbol: nr3c2
Sequence Ontology ID : SO:0000704

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Previous Names: mineralocorticoid receptor (1), MR (1), si:ch211-189l17.1

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(Including Attributions)
Location: Chr: 1 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have several functions, including regulation of cellular process, sequence-specific DNA binding activity, and zinc ion binding activity; involved in multicellular organismal response to  ...
GENE EXPRESSION
All Expression Data: 17 figures from 8 publications
Directly Submitted Expression Data: 7 figures (7 images) from Thisse et al., 2008 [dq017617]
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mn66 Small Deletion Unknown Unknown TALEN
mn67 Small Deletion Unknown Unknown TALEN
sa13656 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nr3c2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    autosomal dominant pseudohypoaldosteronism type 1 Pseudohypoaldosteronism type I, autosomal dominant 177735
    Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy 605115
    DISEASE ASSOCIATED WITH nr3c2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process multicellular organismal response to stress (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000536 (1)
  • InterPro:IPR001628 (1)
  • InterPro:IPR001723 (1)
  • InterPro:IPR013088 (1)
  • InterPro:IPR035500 (1)
  • PROSITE:PS00031 (1)
  • PROSITE:PS51030 (1)
  • PROSITE:PS51843 (1)
  • Pfam:PF00104 (1)
  • Pfam:PF00105 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA nr3c2-201 (1) 2096
    nr3c2-202 (1) 1444
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM nr3c2 No data available
    MARKER RELATIONSHIPS
    nr3c2Contained in: [BAC] CH73-273B10 (1) (order this), CH211-189L17 (1) (order this), DKEY-38N1 (1) (order this), DKEYP-14G8 (1)
    nr3c2Encodes: [EST] dq017617 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001100403 (1) 3540bp
    Genomic GenBank:CR388021 (1) 150805bp
    Select Tool
    Polypeptide UniProtKB:A6YIH7 (1) 970aa
    Sequence Clusters UniGene:95279 (1)
    Sequence Information (all 20)
    OTHER nr3c2 GENE PAGES
  • Alliance (1)
  • Gene:562171 (1)
  • VEGA:OTTDARG00000023640 (1)
  • ORTHOLOGY for nr3c2 (Chr: 1)
    CITATIONS (70)