ZFIN ID: ZDB-GENE-060531-23
Gene Name: nuclear receptor subfamily 3, group C, member 2
Gene Symbol: nr3c2    Nomenclature History

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Previous Names: mineralocorticoid receptor (1), MR (1), mr (1), si:ch211-189l17.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Exhibits steroid hormone binding activity and steroid hormone receptor activity. Involved in multicellular organismal response to stress and response to steroid hormone. Predicted to localize to nucleus. Is expressed in several structures, including blood; eye; heart; liver; and pleuroperitoneal region. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2).
Genome Resources: Alliance (1),  Gene:562171 (1),  Ensembl(GRCz11):ENSDARG00000102082 (1)
GENE EXPRESSION
All Expression Data: 19 figures from 10 publications
Directly Submitted Expression Data: 7 figures (7 images) from Thisse et al., 2008 [dq017617]
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ca402 Indel Exon 2 Premature Stop CRISPR
ct867 Small Deletion Unknown Frameshift, Premature Stop CRISPR
mn66 Small Deletion Exon 2 Frameshift, Premature Stop TALEN
mn67 Small Deletion Exon 2 Frameshift, Premature Stop TALEN
sa13656 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nr3c2 1
    CRISPR2-nr3c2 1
    MO1-nr3c2 N/A 2
    MO2-nr3c2 N/A 2
    TALEN2-nr3c2 2
    DISEASE ASSOCIATED WITH nr3c2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant pseudohypoaldosteronism type 1 Alliance Pseudohypoaldosteronism type I, autosomal dominant 177735
    Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy 605115
    DISEASE ASSOCIATED WITH nr3c2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    autism spectrum disorder nr3c2ct867/ct867(AB/TL) standard conditions Ruzzo et al., 2019
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to steroid hormone (more)
    Cellular Component host cell nucleus (more)
    Molecular Function steroid hormone binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nr3c2-201 (1)    Ensembl 2096
    nr3c2-202 (1)    Ensembl 1444
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nr3c2 No data available
    MARKER RELATIONSHIPS
    nr3c2 Contained in: [BAC] CH73-273B10 (1), CH211-189L17 (1), DKEY-38N1 (1) (order this), DKEYP-14G8 (1)
    nr3c2 Encodes: [EST] dq017617 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001100403 (1) 3540 nt
    Genomic GenBank:CR388021 (1) 150805 nt
    Select Tool
    Polypeptide UniProtKB:A6YIH7 (1) 970 aa
    Sequence Information (all 19)
    ORTHOLOGY for nr3c2 ( Chr: 1 )
    CITATIONS (86)