ZFIN ID: ZDB-GENE-060531-121
Gene Name: laminin, gamma 3
Gene Symbol: lamc3    Nomenclature History

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Previous Name: si:dkey-245l10.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Involved in motor neuron axon guidance. Predicted to localize to the basement membrane. Is expressed in several structures, including fin bud; median fin fold; myoseptum; nervous system; and vasculature. Orthologous to human LAMC3 (laminin subunit gamma 3).
Genome Resources: Alliance (1),  Gene:558958 (1),  Ensembl(GRCz11):ENSDARG00000093572 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la025003Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la025004Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lamc3
    1
    CRISPR2-lamc3
    1
    MO1-lamc3 N/A 1
    MO2-lamc3 N/A 1
    DISEASE ASSOCIATED WITH lamc3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cortical malformations, occipital 614115
    DISEASE ASSOCIATED WITH lamc3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process motor neuron axon guidance (more)
    Cellular Component basement membrane (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR013032 EGF-like, conserved site
    Domain IPR000034 Laminin IV
    Domain IPR000742 EGF-like domain
    Domain IPR002049 Laminin EGF domain
    Domain IPR008211 Laminin, N-terminal
    Homologous_superfamily IPR038684 Laminin, N-terminal domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lamc3-201 (1)    Ensembl 4942
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-lamc3 polyclonal IgG Rabbit IHC Sigma-Aldrich
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lamc3 No data available
    MARKER RELATIONSHIPS
    lamc3 Contained in: [BAC] CH73-198E16 (1), CH211-145F17 (1), DKEY-245L10 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_682251 (1)
    Genomic GenBank:BX296561 (1) 137306 nt
    Select Tool
    Polypeptide UniProtKB:F1QPJ1 (1) 1643 aa
    Sequence Information (all 13)
    ORTHOLOGY for lamc3 ( Chr: 5 )
    CITATIONS (22)