ZFIN ID: ZDB-GENE-060526-180
Gene Name: SEC14-like lipid binding 8
Gene Symbol: sec14l8    Nomenclature History

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Previous Name: si:ch211-89f7.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits GTP binding activity; GTPase activating protein binding activity; and GTPase activity. Involved in Wnt signaling pathway, calcium modulating pathway; angioblast cell migration from lateral mesoderm to midline; and regulation of morphogenesis of an epithelium. Localizes to extrinsic component of plasma membrane. Is expressed in blastomere; posterior cardinal vein; trunk vasculature; vascular cord; and vasculature. Orthologous to several human genes including SEC14L2 (SEC14 like lipid binding 2) and SEC14L3 (SEC14 like lipid binding 3).
Genome Resources: Alliance (1),  Gene:558964 (1),  Ensembl(GRCz11):ENSDARG00000059729 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20358 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tsu16 Small Deletion Start Codon Start Loss TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • tsu17 Small Deletion Start Codon Start Loss TALEN
    tsu18 Small Deletion Start Codon Start Loss TALEN
    tsu19 Small Deletion Start Codon Start Loss TALEN
    tsu36cd Small Deletion Exon 5 Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-sec14l8 1
    MO1-sec14l8 N/A 1
    MO2-sec14l8 N/A 2
    MO3-sec14l8 N/A 1
    TALEN1-sec14l8 1
    DISEASE ASSOCIATED WITH sec14l8 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sec14l8 VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sec14l8-201 (1)    Ensembl 2353
    ncRNA sec14l8-002 (1)    Ensembl 822
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sec14l8 No data available
    MARKER RELATIONSHIPS
    sec14l8 Contained in: [BAC] CH211-42H14 (1), CH211-89F7 (1)
    sec14l8 Encodes: [EST] fm06b11
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001099993 (1) 1188 nt
    Genomic GenBank:BX957246 (1) 186135 nt
    Select Tool
    Polypeptide UniProtKB:A2BIR0 (1) 395 aa
    Sequence Information (all 10)
    ORTHOLOGY for sec14l8 ( Chr: 5 )
    CITATIONS (14)