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ZIRC
ZFIN ID: ZDB-GENE-060503-759
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Gene Name: ataxin 1a
Gene Symbol: atxn1a    Nomenclature History

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Previous Names: atxn1b (1), si:ch211-125a6.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have RNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and nervous system development. Localizes to the nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1. Is expressed in cerebellum. Orthologous to human ATXN1 (ataxin 1).
Genome Resources: Alliance (1),  Gene:557340 (1),  Ensembl(GRCz11):ENSDARG00000061687 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23557 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH atxn1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spinocerebellar ataxia type 1 Alliance Spinocerebellar ataxia 1 164400
    DISEASE ASSOCIATED WITH atxn1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function RNA binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003652 (1)
  • InterPro:IPR020997 (1)
  • InterPro:IPR036096 (1)
  • InterPro:IPR040172 (1)
  • PROSITE:PS51148 (1)
  • Pfam:PF08517 (1)
  • Pfam:PF12547 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atxn1a-201 (1)    Ensembl 2346
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-atxn1 polyclonal IgG Rabbit IHC 2
    Ab2-atxn1 polyclonal Rabbit WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atxn1a No data available
    MARKER RELATIONSHIPS
    atxn1a Contained in: [BAC] CH211-125A6 (1) (order this)
    atxn1a Encodes: [cDNA] MGC:198436 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001044826 (1) 2346 bp
    Select Tool
    Genomic RefSeq:NW_018395054 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QBY9 (1) 781 aa
    Select Tool
    Sequence Clusters UniGene:87340 (1)
    Sequence Information (all 25)
    ORTHOLOGY for atxn1a ( Chr: 19 )
    CITATIONS (20)