ZFIN ID: ZDB-GENE-060503-416
Gene Name: solute carrier family 17 member 8
Gene Symbol: slc17a8    Nomenclature History

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Previous Names: asteroid (1), si:ch211-264e16.4, vesicular glutamate transporter 3 (1), vglut3 (2)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have L-glutamate transmembrane transporter activity. Involved in equilibrioception; regulation of synapse structure or activity; and vestibular reflex. Predicted to localize to the excitatory synapse and integral component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Is expressed in hair cell; hair cell anterior macula; inner ear; neuromast; and neuromast hair cell. Orthologous to human SLC17A8 (solute carrier family 17 member 8).
Genome Resources: Alliance (1),  Gene:563467 (1),  Ensembl(GRCz11):ENSDARG00000057728 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11329 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36606 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • vo1 Point Mutation Intron 2 Splicing Variant ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-slc17a8 N/A 1
    MO2-slc17a8 N/A 1
    DISEASE ASSOCIATED WITH slc17a8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 25 Alliance Deafness, autosomal dominant 25 605583
    DISEASE ASSOCIATED WITH slc17a8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process equilibrioception (more)
    Cellular Component cell junction (more)
    Molecular Function symporter activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR011701 Major facilitator superfamily
    Domain IPR020846 Major facilitator superfamily domain
    Homologous_superfamily IPR036259 MFS transporter superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc17a8-201 (1)    Ensembl 1773
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-slc17a8 polyclonal Rabbit IHC 8
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc17a8 No data available
    MARKER RELATIONSHIPS
    slc17a8 Contained in: [BAC] CH211-264E16 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001082835 (1) 1773 bp
    Genomic GenBank:CR536616 (1) 154119 bp
    Select Tool
    Polypeptide UniProtKB:B5AU16 (1) 590 aa
    Sequence Information (all 9)
    ORTHOLOGY for slc17a8 ( Chr: 18 )
    CITATIONS (31)