ZFIN Gene: lman1

ZFIN ID: ZDB-GENE-060201-4

ZFIN ID: ZDB-GENE-060201-4

Gene Name:

lectin, mannose-binding, 1

Gene Symbol:

lman1 Nomenclature History

Previous Names:

fc54c09, fi36e01, wu:fc54c09, wu:fi36e01

Gene Type:

protein_coding_gene

Location:

Chr: 21 Mapping Details/Browsers

Description:

Predicted to have mannose binding activity. Involved in cellular response to estrogen stimulus. Predicted to localize to several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including axis; hatching gland; head; immature eye; and optic primordium. Human ortholog(s) of this gene implicated in factor V deficiency and factor XIII deficiency. Orthologous to human LMAN1 (lectin, mannose binding 1).

Genome Resources:

Alliance (1), Gene:559775 (1), Ensembl(GRCz11):ENSDARG00000069980 (2)

GENE EXPRESSION
All Expression Data:	22 figures from 4 publications
Directly Submitted Expression Data:	6 figures (12 images) from Rauch et al., 2003 [fc54c09]
	7 figures (14 images) from Thisse et al., 2004 [IMAGE:7143659]
	7 figures (13 images) from Thisse et al., 2004 [IMAGE:7147380]
Wild-type Stages, Structures:	Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
	axis diencephalon floor plate hatching gland head immature eye notochord optic primordium optic vesicle otic vesicle pancreas pharyngeal arch pharyngeal arch 3-7 skeleton polster somite unspecified
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa13208	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa16718	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37243	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa43588	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH lman1 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Combined factor V and VIII deficiency	227300

DISEASE ASSOCIATED WITH lman1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cellular response to estrogen stimulus (more)
Cellular Component	integral component of membrane (more)
Molecular Function	mannose binding (more)

GO Terms (all 11)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	lman1-201 (1)	2104	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	lman1-202 (1)	300	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM lman1 No data available

MARKER RELATIONSHIPS

lman1 Contained in:	[BAC] CH73-306K8 (1), CH211-233A1 (1)
lman1 Contains:	[SNP] rs3729079 (1), rs3729080 (1), rs3729081 (1), rs3729082 (1), rs3729083 (1), rs3729084 (1), rs3729085 (1)
lman1 Encodes:	[EST] fc54c09 (order this), fi36e01, IMAGE:7143659 (1), IMAGE:7147380 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_683569 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:BX248399 (1)	158884 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A2R8Q848 (1)	577 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 35)

ORTHOLOGY for lman1 ( Chr: 21 )

CITATIONS (30)

{{control.fieldName}} Edit

Attributions

Add new Alias

Attributions for Alias: {{control.newAlias}}

Delete Alias: