ZFIN ID: ZDB-GENE-051031-1
Gene Name: integrin, alpha 2b
Gene Symbol: itga2b    Nomenclature History

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Previous Names: CD41 (1), GPIIb (2), si:dkey-27b3.6 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Involved in angiogenesis; blood coagulation; and endothelial cell proliferation. Localizes to the integrin complex. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Is expressed in blood; thrombocyte; and ventral wall of dorsal aorta. Orthologous to human ITGA2B (integrin subunit alpha 2b).
Genome Resources: Alliance (1),  Gene:445380 (1),  Ensembl(GRCz11):ENSDARG00000018687 (1)
GENE EXPRESSION
All Expression Data: 20 figures from 15 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa83 Point Mutation Unknown Splice Site ENU
    sa10134 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26046 Point Mutation Unknown Splice Site ENU
    sa30831 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40051 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40052 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40053 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-itga2b N/A 1
    MO2-itga2b N/A 1
    MO3-itga2b N/A 1
    MO4-itga2b N/A 2
    DISEASE ASSOCIATED WITH itga2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Glanzmann's thrombasthenia Alliance Glanzmann thrombasthenia 273800
    platelet-type bleeding disorder 16 Alliance Bleeding disorder, platelet-type, 16, autosomal dominant 187800
    Thrombocytopenia, neonatal alloimmune, BAK antigen related
    DISEASE ASSOCIATED WITH itga2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood coagulation (more)
    Cellular Component integrin complex (more)
    Molecular Function protein binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
    Domain IPR013649 Integrin alpha-2
    Family IPR000413 Integrin alpha chain
    Homologous_superfamily IPR028994 Integrin alpha, N-terminal
    Homologous_superfamily IPR032695 Integrin domain superfamily
    Repeat IPR013517 FG-GAP repeat
    Repeat IPR013519 Integrin alpha beta-propellor
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itga2b-201 (1)    Ensembl 3755
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-itga2b polyclonal Rabbit 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itga2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-6.0itga2b:EGFP) itga2b EGFP Danio rerio 1 141
    tg(itga2b:gfp) itga2b GFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    itga2b Contained in: [BAC] CH73-54A8
    itga2b Encodes: [cDNA] MGC:194612 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003857 (1) 3673 nt
    Genomic GenBank:CT573446 (1) 75900 nt
    Select Tool
    Polypeptide UniProtKB:B3DIZ6 (1) 1037 aa
    Sequence Information (all 11)
    ORTHOLOGY for itga2b ( Chr: 3 )
    CITATIONS (68)