Gene

itga2b

ID
ZDB-GENE-051031-1
Name
integrin, alpha 2b
Symbol
itga2b Nomenclature History
Previous Names
  • CD41 (1)
  • GPIIb (2)
  • si:dkey-27b3.6 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Involved in angiogenesis; blood coagulation; and endothelial cell proliferation. Localizes to integrin complex. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Is expressed in blood; thrombocyte; and ventral wall of dorsal aorta. Orthologous to human ITGA2B (integrin subunit alpha 2b).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
27 figures from 20 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With itga2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bleeding disorder, platelet-type, 16, autosomal dominant 187800
Glanzmann thrombasthenia 1 273800
Thrombocytopenia, neonatal alloimmune, BAK antigen related
Associated With itga2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Domain IPR013649 Integrin alpha, first immunoglubulin-like domain
Domain IPR048285 Integrin alpha, second immunoglobulin-like domain
Domain IPR048286 Integrin alpha, third immunoglobulin-like domain
Family IPR000413 Integrin alpha chain
Homologous_superfamily IPR028994 Integrin alpha, N-terminal
Homologous_superfamily IPR032695 Integrin domain superfamily
Repeat IPR013517 FG-GAP repeat
Repeat IPR013519 Integrin alpha beta-propellor
Domain Details Per Protein
Protein Length FG-GAP repeat Integrin alpha beta-propellor Integrin alpha chain Integrin alpha chain, C-terminal cytoplasmic region, conserved site Integrin alpha, first immunoglubulin-like domain Integrin alpha, N-terminal Integrin alpha, second immunoglobulin-like domain Integrin alpha, third immunoglobulin-like domain Integrin domain superfamily
UniProtKB:Q6EIY7 1037
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA itga2b-201 (1) Havana 3755 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-itga2b monoclonal Mouse
1
Ab1-itga2b polyclonal Rabbit
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations