ZFIN ID: ZDB-GENE-051031-1
Gene Name: integrin, alpha 2b
Gene Symbol: itga2b
Sequence Ontology ID : SO:0000704

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Previous Names: CD41 (1), GPIIb (1), si:dkey-27b3.6 (1)

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(Including Attributions)
Location: Chr: 3 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Involved in angiogenesis, blood coagulation, and endothelial cell proliferation; localizes to the integrin complex; orthologous to human ITGA2B (integrin subunit alpha 2b).
GENE EXPRESSION
All Expression Data: 20 figures from 15 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
PHENOTYPE
Data: 7 figures from 3 publications
Observed in:
DISEASE ASSOCIATED WITH itga2b HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Glanzmann's thrombasthenia Glanzmann thrombasthenia 273800
platelet-type bleeding disorder 16 Bleeding disorder, platelet-type, 16, autosomal dominant 187800
Thrombocytopenia, neonatal alloimmune, BAK antigen related
DISEASE ASSOCIATED WITH itga2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process blood coagulation (more)
Cellular Component integrin complex (more)
Molecular Function protein binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000413 (1)
  • InterPro:IPR013517 (1)
  • InterPro:IPR013519 (1)
  • InterPro:IPR013649 (1)
  • InterPro:IPR018184 (1)
  • InterPro:IPR028994 (1)
  • InterPro:IPR032695 (1)
  • PROSITE:PS00242 (1)
  • PROSITE:PS51470 (1)
  • Pfam:PF00357 (1)
  • Pfam:PF01839 (1)
  • Pfam:PF08441 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA itga2b-201 (1) 3755
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM itga2b
    MARKER RELATIONSHIPS
    itga2bContained in: [BAC] CH73-54A8 (order this)
    itga2bEncodes: [cDNA] MGC:194612 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001003857 (1) 3673bp
    Genomic GenBank:CT573446 (1) 75900bp
    Select Tool
    Polypeptide UniProtKB:B3DIZ6 (1) 1037aa
    Sequence Clusters UniGene:85730 (1)
    Sequence Information (all 12)
    OTHER itga2b GENE PAGES
  • Alliance (1)
  • Gene:445380 (1)
  • VEGA:OTTDARG00000027165 (1)
  • Ensembl(GRCz11):ENSDARG00000018687 (1)
  • ORTHOLOGY for itga2b (Chr: 3)
    CITATIONS (63)