ZFIN ID: ZDB-GENE-051014-1
Gene Name: sphingomyelin phosphodiesterase 2a
Gene Symbol: smpd2a    Nomenclature History

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Previous Names: smpd2, neutral SMase I (1), neutral sphingomyelinase (1), nSMase1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Exhibits sphingomyelin phosphodiesterase activity. Involved in several processes, including cellular response to temperature stimulus; sphingolipid mediated signaling pathway; and sphingolipid metabolic process. Localizes to the Golgi apparatus. Is expressed in yolk syncytial layer. Orthologous to human SMPD2 (sphingomyelin phosphodiesterase 2).
Genome Resources: Alliance (1),  Gene:567548 (1),  Ensembl(GRCz11):ENSDARG00000040523 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2004 [IMAGE:7156202]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-smpd2a N/A 1
MO2-smpd2a N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH smpd2a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH smpd2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cellular response to temperature stimulus (more)
Cellular Component Golgi apparatus (more)
Molecular Function sphingomyelin phosphodiesterase activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR005135 Endonuclease/exonuclease/phosphatase
Family IPR038772 Sphingomyelin phosphodiesterase 2-like
Homologous_superfamily IPR036691 Endonuclease/exonuclease/phosphatase superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA smpd2a-201 (1)    Ensembl 1702
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-smpd2a polyclonal Rabbit 1
Ab2-smpd2a polyclonal Rabbit 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM smpd2a No data available
MARKER RELATIONSHIPS
smpd2a Contained in: [Fosmid] CH1073-182O11 (1)
smpd2a Encodes: [EST] IMAGE:7156202 (1)
[cDNA] MGC:194512 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001030219 (1) 1263 nt
Genomic GenBank:CU570774 (1) 33235 nt
Select Tool
Polypeptide UniProtKB:F1QUD7 (1) 421 aa
Sequence Information (all 17)
ORTHOLOGY for smpd2a ( Chr: 23 )
CITATIONS (19)