ZFIN ID: ZDB-GENE-050913-156
Gene Name: establishment of sister chromatid cohesion N-acetyltransferase 2
Gene Symbol: esco2    Nomenclature History

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Previous Names: loc157570, si:dkey-217m5.6, un-named hi2865, unm hi2865, zgc:111795 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have acetyltransferase activity. Involved in several processes, including positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; sister chromatid cohesion; and tissue regeneration. Predicted to localize to chromatin. Is expressed in digestive system; heart; nervous system; otic vesicle; and pectoral fin. Used to study Roberts syndrome. Human ortholog(s) of this gene implicated in Roberts syndrome and SC phocomelia syndrome. Orthologous to human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2).
Genome Resources: Alliance (1),  Gene:445395 (1),  Ensembl(GRCz11):ENSDARG00000014685 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:111795]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi2865Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14007 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16629 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • uab1 Insertion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-esco2 1
    CRISPR2-esco2
    1
    CRISPR3-esco2
    1
    CRISPR4-esco2
    1
    CRISPR5-esco2
    1
    MO1-esco2 N/A 4
    MO2-esco2 N/A 2
    DISEASE ASSOCIATED WITH esco2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Roberts syndrome Alliance Roberts syndrome 268300
    SC phocomelia syndrome 269000
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fin regeneration (more)
    Cellular Component chromatin (more)
    Molecular Function acetyltransferase activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA esco2-201 (1)    Ensembl 2339
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-esco2 polyclonal Rabbit WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM esco2 No data available
    MARKER RELATIONSHIPS
    esco2 Contained in: [BAC] DKEY-217M5 (1) (order this)
    esco2 Encodes: [cDNA] MGC:111795 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003872 (1) 2350 nt
    Genomic GenBank:AL845306 (1) 186675 nt
    Select Tool
    Polypeptide UniProtKB:Q5SPR8 (1) 609 aa
    Sequence Information (all 14)
    ORTHOLOGY for esco2 ( Chr: 20 )
    CITATIONS (40)