Gene

esco2

ID
ZDB-GENE-050913-156
Name
establishment of sister chromatid cohesion N-acetyltransferase 2
Symbol
esco2 Nomenclature History
Previous Names
  • loc157570
  • si:dkey-217m5.6
  • un-named hi2865
  • unm hi2865
  • zgc:111795 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have acetyltransferase activity. Involved in several processes, including bone regeneration; fin regeneration; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to chromatin. Is expressed in digestive system; heart; nervous system; otic vesicle; and pectoral fin. Used to study Roberts syndrome. Human ortholog(s) of this gene implicated in Roberts syndrome. Orthologous to human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2).
Genome Resources
Note
None
Expression
All Expression Data
6 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With esco2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Roberts syndrome Alliance Roberts-SC phocomelia syndrome 268300
Juberg-Hayward syndrome 216100
Associated With esco2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR028005 N-acetyltransferase ESCO, zinc-finger
Domain IPR028009 N-acetyltransferase ESCO, acetyl-transferase domain
Domain Details Per Protein
Protein Length N-acetyltransferase ESCO, acetyl-transferase domain N-acetyltransferase ESCO, zinc-finger
UniProtKB:Q5SPR8 609
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-esco2 polyclonal Rabbit
  • WB
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations