Community Action Needed: Please respond to the NIH RFI
Gene

dgat2

ID
ZDB-GENE-050913-15
Name
diacylglycerol O-acyltransferase 2
Symbol
dgat2 Nomenclature History
Previous Names
  • zgc:113394
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable diacylglycerol O-acyltransferase activity. Acts upstream of or within lipid homeostasis; regulation of response to endoplasmic reticulum stress; and response to (R)-carnitine. Predicted to be located in lipid droplet and perinuclear endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in male organism. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to several human genes including DGAT2 (diacylglycerol O-acyltransferase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from O'Hare et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dgat2 Human Ortholog
No data available
Associated With dgat2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR007130 Diacylglycerol acyltransferase
Domain Details Per Protein
Protein Length Diacylglycerol acyltransferase
UniProtKB:F1Q578 366
UniProtKB:Q4V9F0 361
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations