ZFIN ID: ZDB-GENE-050913-15
Gene Name: diacylglycerol O-acyltransferase 2
Gene Symbol: dgat2    Nomenclature History

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Previous Name: zgc:113394

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have diacylglycerol O-acyltransferase activity. Involved in lipid homeostasis; regulation of response to endoplasmic reticulum stress; and response to (R)-carnitine. Predicted to localize to endoplasmic reticulum membrane; lipid droplet; and perinuclear endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Is expressed in male organism. Orthologous to several human genes including DGAT2 (diacylglycerol O-acyltransferase 2).
Genome Resources: Alliance (1),  Gene:565316 (1),  Ensembl(GRCz11):ENSDARG00000018846 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 6 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011848Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13945 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dgat2 N/A 1
    DISEASE ASSOCIATED WITH dgat2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dgat2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lipid homeostasis (more)
    Cellular Component endoplasmic reticulum membrane (more)
    Molecular Function diacylglycerol O-acyltransferase activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dgat2-202 (1)    Ensembl 1593
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dgat2 No data available
    MARKER RELATIONSHIPS
    dgat2 Contained in: [BAC] CH211-147G3 (1)
    dgat2 Encodes: [cDNA] MGC:113394 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001030196 (1) 1600 nt
    Genomic GenBank:CR293504 (1) 165086 nt
    Select Tool
    Polypeptide UniProtKB:F1Q578 (1) 366 aa
    Sequence Information (all 10)
    ORTHOLOGY for dgat2 ( Chr: 10 )
    CITATIONS (67)