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General Information
ZIRC
ZFIN ID: ZDB-GENE-050522-503
Gene Name: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Gene Symbol: nr3c1
Sequence Ontology ID : SO:0000704

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Attributions

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Previous Names: fb13f09, glucocorticoid receptor, gr, utouto (1), utut, wu:fb13f09, zgc:113038

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(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits glucocorticoid receptor activity. Involved in several processes, including cation transport; metal ion homeostasis; and response to glucocorticoid. Localizes to the cytoplasm and nucleus.  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ca401 Small Deletion Unknown Unknown CRISPR
ia30 Insertion Exon 2 Frameshift, Premature Stop CRISPR
mn61 Small Deletion Exon 2 Frameshift, Premature Stop TALEN
mn62 Indel Exon 2 Frameshift, Premature Stop TALEN
mn63 Indel Exon 5 Frameshift, Premature Stop TALEN
mn64 Indel Exon 5 Frameshift, Premature Stop TALEN
mn65 Indel Exon 5 Frameshift, Premature Stop TALEN
s357 Point Mutation Unknown Missense ENU
  • Baier Lab
  • sa17694 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH nr3c1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Glucocorticoid resistance 615962
    DISEASE ASSOCIATED WITH nr3c1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    mental depression nr3c1s357/s357 standard conditions Ziv et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription, DNA-templated (more)
    Cellular Component cytoplasm (more)
    Molecular Function glucocorticoid receptor activity (more)
    GO Terms (all 29)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA nr3c1-201 (1) 4461
    nr3c1-202 (1) 2650
    nr3c1-203 (1) 1720
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM nr3c1
    MARKER RELATIONSHIPS
    nr3c1Contained in: [BAC] CH211-119P14 (1) (order this)
    nr3c1Encodes: [EST] dq017615 (1) (order this), fb13f09
    [cDNA] MGC:113038 (1) (order this), MGC:191720 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020711 (1) 2262bp
    Genomic GenBank:BX470157 (1) 201228bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QN75 (1) 746aa
    Sequence Clusters UniGene:132249 (1)
    Sequence Information (all 39)
    ORTHOLOGY for nr3c1 (Chr: 14)
    CITATIONS (139)