ZFIN ID: ZDB-GENE-050522-503
Gene Name: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Gene Symbol: nr3c1    Nomenclature History

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Previous Names: fb13f09, glucocorticoid receptor, gr (1), utouto (1), utut, wu:fb13f09, zgc:113038

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits glucocorticoid receptor activity. Involved in several processes, including cation transport; metal ion homeostasis; and response to glucocorticoid. Localizes to cytoplasm and nucleus. Used to study mental depression. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Is expressed in several structures, including blastodisc; digestive system; eye; gill; and pleuroperitoneal region. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1).
Genome Resources: Alliance (1),  Gene:553740 (1),  Ensembl(GRCz11):ENSDARG00000025032 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ca401 Small Deletion Exon 2 Premature Stop CRISPR
ia30 Insertion Exon 2 Frameshift, Premature Stop CRISPR
mn61 Small Deletion Exon 2 Frameshift, Premature Stop TALEN
mn62 Indel Exon 2 Frameshift, Premature Stop TALEN
mn63 Indel Exon 5 Frameshift, Premature Stop TALEN
mn64 Indel Exon 5 Frameshift, Premature Stop TALEN
mn65 Indel Exon 5 Frameshift, Premature Stop TALEN
s357 Point Mutation Unknown Missense ENU
  • Baier Lab
  • sa17694 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nr3c1 2
    CRISPR2-nr3c1 1
    MO1-nr3c1 N/A 8
    MO2-nr3c1 N/A 6
    MO3-nr3c1 N/A 1
    MO4-nr3c1 N/A 5
    MO5-nr3c1 N/A 5
    MO6-nr3c1 N/A 1
    MO7-nr3c1 N/A 1
    TALEN1-nr3c1 4
    TALEN2-nr3c1 1
    DISEASE ASSOCIATED WITH nr3c1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Glucocorticoid resistance 615962
    DISEASE ASSOCIATED WITH nr3c1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    mental depression nr3c1s357/s357 standard conditions Ziv et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription, DNA-templated (more)
    Cellular Component cytoplasm (more)
    Molecular Function glucocorticoid receptor activity (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nr3c1-201 (1)    Ensembl 4461
    nr3c1-202 (1)    Ensembl 2650
    nr3c1-203 (1)    Ensembl 1720
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-nr3c1 polyclonal Rabbit 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nr3c1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(14xUAS:d1EGFP-nr3c1) UAS d1EGFPnr3c1 Danio rerio 1 1
    MARKER RELATIONSHIPS
    nr3c1 Contained in: [BAC] CH211-119P14 (1)
    nr3c1 Encodes: [EST] dq017615 (1), fb13f09
    [cDNA] MGC:113038 (1), MGC:191720 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001020711 (1) 2262 nt
    Genomic GenBank:BX470157 (1) 201228 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QN75 (1) 746 aa
    Sequence Information (all 37)
    ORTHOLOGY for nr3c1 ( Chr: 14 )
    CITATIONS (159)