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Gene

nr3c1

ID
ZDB-GENE-050522-503
Name
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Symbol
nr3c1 Nomenclature History
Previous Names
  • fb13f09
  • glucocorticoid receptor
  • gr (1)
  • utouto (1)
  • utut
  • wu:fb13f09
  • zgc:113038
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Enables glucocorticoid receptor activity. Acts upstream of or within several processes, including cation transport; metal ion homeostasis; and response to glucocorticoid. Located in cytoplasm and nucleus. Is expressed in several structures, including blastodisc; digestive system; eye; gill; and pleuroperitoneal region. Used to study mental depression. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
39 figures from 24 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
45 figures from 18 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nr3c1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Glucocorticoid resistance 615962
Associated With nr3c1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001409 Glucocorticoid receptor
Family IPR001723 Nuclear hormone receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Glucocorticoid receptor Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:F6PEW1 739
UniProtKB:A0A2R8RNZ4 746
UniProtKB:Q501U9 471
UniProtKB:A0A2R8QN75 746
UniProtKB:O42541 34
UniProtKB:B1NAT5 737
UniProtKB:Q1L691 313
UniProtKB:Q1XHK0 746
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-nr3c1 polyclonal Rabbit
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations